NMDA receptor antagonists impair motor performance in immature rats
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- 2-amino-5-fosfonovalerát analogy a deriváty farmakologie MeSH
- antagonisté excitačních aminokyselin farmakologie MeSH
- časové faktory MeSH
- chování zvířat účinky léků MeSH
- dizocilpinmaleát farmakologie MeSH
- krysa rodu Rattus MeSH
- novorozená zvířata MeSH
- potkani Wistar MeSH
- psychomotorický výkon účinky léků MeSH
- receptory N-methyl-D-aspartátu antagonisté a inhibitory MeSH
- věkové faktory MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 2-amino-4-methyl-5-phosphono-3-pentenoic acid MeSH Prohlížeč
- 2-amino-5-fosfonovalerát MeSH
- antagonisté excitačních aminokyselin MeSH
- dizocilpinmaleát MeSH
- receptory N-methyl-D-aspartátu MeSH
RATIONALE: Antagonists of NMDA receptors are excellent anticonvulsants in adult animals but serious side effects prevent their clinical use. The effects of two antagonists on motor performance were studied to find out if they develop in parallel with previously described anticonvulsant action. METHODS: Motor performance of 12-, 18- and 25-day-old rats was studied using a battery of tests (surface righting, negative geotaxis, bar holding and wire mesh ascending and three age-specific tests). A competitive NMDA antagonist CGP 40116 (0.1, 0.5 and/or 1 mg/kg IP) and a noncompetitive one dizocilpine (0.1, 0.5 and/or 1 mg/kg IP) were tested. RESULTS: Ten minutes after CGP 40116, the performance was compromised in all tests but there was negative geotaxis in all age groups. A decrease in efficacy with age was clearly demonstrated. Righting ability remained untouched in 25-day-old animals. Dizocilpine also influenced the performance in all tests but righting (compromised only in the youngest group) when studied 10 min after the injection. The relation to age was not so marked as with CGP 40116. When the tests were applied 4 h after dizocilpine administration the results were similar to those at 10-min interval. Twenty-four hours after dizocilpine only cliff avoidance exhibited prolonged latencies in 12-day-old rats but significant effects were observed in 18-day-old (negative geotaxis, bar holding and wire mesh ascending) as well as 25-day-old animals (bar holding, jumping down with choice). CONCLUSIONS: The acute effects of both NMDA antagonists studied decreased with age; this age-related change was more marked with CGP 40116 than with dizocilpine. In contrast, duration of dizocilpine effects did not exhibit a clear developmental tendency.
Citace poskytuje Crossref.org
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