Development of the vestigial tooth primordia as part of mouse odontogenesis
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- MeSH
- Apoptosis MeSH
- Embryo, Nonmammalian MeSH
- Embryo, Mammalian physiology MeSH
- Embryonic and Fetal Development MeSH
- Mice embryology MeSH
- Odontogenesis physiology MeSH
- Reptiles embryology MeSH
- Tooth embryology MeSH
- Animals MeSH
- Check Tag
- Mice embryology MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
The mouse functional dentition comprises one incisor separated from three molars by a toothless diastema in each dental quadrant. Between the incisor and molars, the embryonic tooth pattern also includes vestigial dental primordia, which undergo regression involving apoptosis in their epithelium. Apoptosis appears to play an important role in achieving the specific tooth pattern in the mouse. We documented similarities in the folding mechanism allowing the formation of the dental lamina in mice as well as in reptiles. While further budding on this dental lamina gives rise to many individual simple tooth primordia in crocodiles and lizards, budding morphogenesis of several simple tooth primordia appears to be integrated in the mouse, giving rise to enamel organs of a complex nature. The differentiation of a mammalian tooth germ during both ontogeny and phylogeny might thus include the concrescence (connation) of more primordia, putatively corresponding to simple teeth in mammalian ancestors.
References provided by Crossref.org
Role of Cell Death in Cellular Processes During Odontogenesis
Developmental variability channels mouse molar evolution
Sprouty gene dosage influences temporal-spatial dynamics of primary enamel knot formation
Three-dimensional analysis of the early development of the dentition
Apoptotic signaling in mouse odontogenesis
Patterning by heritage in mouse molar row development
