Development of the vestigial tooth primordia as part of mouse odontogenesis
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
- MeSH
- apoptóza MeSH
- embryo nesavčí MeSH
- embryo savčí fyziologie MeSH
- embryonální a fetální vývoj MeSH
- myši embryologie MeSH
- odontogeneze fyziologie MeSH
- plazi embryologie MeSH
- zuby embryologie MeSH
- zvířata MeSH
- Check Tag
- myši embryologie MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
The mouse functional dentition comprises one incisor separated from three molars by a toothless diastema in each dental quadrant. Between the incisor and molars, the embryonic tooth pattern also includes vestigial dental primordia, which undergo regression involving apoptosis in their epithelium. Apoptosis appears to play an important role in achieving the specific tooth pattern in the mouse. We documented similarities in the folding mechanism allowing the formation of the dental lamina in mice as well as in reptiles. While further budding on this dental lamina gives rise to many individual simple tooth primordia in crocodiles and lizards, budding morphogenesis of several simple tooth primordia appears to be integrated in the mouse, giving rise to enamel organs of a complex nature. The differentiation of a mammalian tooth germ during both ontogeny and phylogeny might thus include the concrescence (connation) of more primordia, putatively corresponding to simple teeth in mammalian ancestors.
Citace poskytuje Crossref.org
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