Changes in plasma membrane fluidity lower the sensitivity of S. cerevisiae to killer toxin K1
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15058188
DOI
10.1007/bf02931510
Knihovny.cz E-resources
- MeSH
- Anti-Infective Agents, Local pharmacology MeSH
- Cell Membrane drug effects MeSH
- Diphenylhexatriene MeSH
- Ethanol pharmacology MeSH
- Membrane Fluidity drug effects MeSH
- Fluorescent Dyes MeSH
- Killer Factors, Yeast MeSH
- Culture Media pharmacology MeSH
- Mycotoxins pharmacology MeSH
- Fatty Acids, Unsaturated pharmacology MeSH
- Saccharomyces cerevisiae drug effects growth & development metabolism MeSH
- Temperature MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Infective Agents, Local MeSH
- Diphenylhexatriene MeSH
- Ethanol MeSH
- Fluorescent Dyes MeSH
- K1 killer toxin MeSH Browser
- Killer Factors, Yeast MeSH
- Culture Media MeSH
- Mycotoxins MeSH
- Fatty Acids, Unsaturated MeSH
The possible correlation between plasma membrane fluidity changes induced by modified cultivation conditions and cell sensitivity to the killer toxin K1 of Saccharomyces cerevisiae were investigated. Cells grown under standard conditions exhibited high toxin sensitivity. Both a membrane fluidity drop and fluidity rise brought about markedly reduced sensitivity to the toxin. These results do not fit the hypothesis of physiological relevance of direct toxin-lipid interaction, suggesting that the essential event in killer toxin action is interaction with membrane protein(s) that can be negatively influenced by any changes of membrane fluidity.
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