Polymeric anticancer drugs with pH-controlled activation
Language English Country Netherlands Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
15066758
DOI
10.1016/j.addr.2003.10.040
PII: S0169409X03002837
Knihovny.cz E-resources
- MeSH
- Immunoconjugates chemistry pharmacology MeSH
- Hydrogen-Ion Concentration MeSH
- Humans MeSH
- Drug Carriers MeSH
- Polymers chemistry pharmacology MeSH
- Prodrugs chemistry pharmacology MeSH
- Antineoplastic Agents chemistry pharmacology MeSH
- Solubility MeSH
- Water chemistry MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Immunoconjugates MeSH
- Drug Carriers MeSH
- Polymers MeSH
- Prodrugs MeSH
- Antineoplastic Agents MeSH
- Water MeSH
Use of macromolecular water-soluble carriers of anti-cancer drugs represents a promising approach to cancer therapy. Release of drugs from the carrier system is a prerequisite for therapeutic activity of most macromolecular anti-cancer conjugates. Incorporation of acid-sensitive spacers between the drug and carrier enables release of an active drug from the carrier in a tumor tissue, either in slightly acidic extracellular fluids or, after endocytosis, in endosomes or lysosomes of cancer cells. This paper reviews advances in development and study of properties of various acid-sensitive macromolecular drug delivery systems, starting from simple polymer-drug conjugates to ending with site-specific antibody-targeted polymer-drug conjugates.
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