Lymphocyte subpopulations and immunoglobulin levels in Hodgkin's disease survivors
Jazyk angličtina Země Slovensko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
15254656
Knihovny.cz E-zdroje
- MeSH
- antigeny CD20 biosyntéza MeSH
- antigeny CD3 biosyntéza MeSH
- B-lymfocyty metabolismus MeSH
- CD4-pozitivní T-lymfocyty metabolismus MeSH
- CD8-pozitivní T-lymfocyty metabolismus MeSH
- cholesterol metabolismus MeSH
- DNA metabolismus MeSH
- dospělí MeSH
- Hodgkinova nemoc krev imunologie MeSH
- imunoglobulin A chemie MeSH
- imunoglobulin E chemie MeSH
- imunoglobulin G chemie MeSH
- imunoglobulin M chemie MeSH
- imunoglobuliny metabolismus MeSH
- lidé MeSH
- podskupiny lymfocytů * MeSH
- receptory IgG biosyntéza MeSH
- T-lymfocyty pomocné-indukující imunologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antigeny CD20 MeSH
- antigeny CD3 MeSH
- cholesterol MeSH
- DNA MeSH
- imunoglobulin A MeSH
- imunoglobulin E MeSH
- imunoglobulin G MeSH
- imunoglobulin M MeSH
- imunoglobuliny MeSH
- receptory IgG MeSH
We investigated the frequency of lymphocyte populations (CD3+ /T lymphocytes/, CD4+ /helpers/, CD8+ /suppressor and cytotoxic/, CD3- CD16+ /NK cells/, CD3+ HLA-DR+ /activated T lymphocytes/, and CD20+ /B lymphocytes/) and immunoglobulin G, A, M, and E levels in a group of two hundred twenty nine Hodgkińs disease long term survivors. The most frequent pathological findings were increased IgE levels, decreased CD3+ and CD4+ proportions, an increased CD20+ proportion and especially a low CD4/CD8 proportion. Decreased CD3+ and CD4+ and increased CD20+ proportions were more frequently found in the group with recurrent infections. IgM and IgA levels were positively correlated with plasmatic cholesterol and triacylglycerols levels. We suppose that immunological defects (increase of IgE levels, decreased T and helper lymphocytes) in Hodgkińs disease survivors are inherent and are not related to atopy. Examination of lymphocyte subpopulations may be helpful in the prediction of an increased risk of recurrent infections.
