Cancer evolution and immunity in a rat colorectal carcinogenesis model
Language English Country Greece Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15375547
Knihovny.cz E-resources
- MeSH
- Killer Cells, Natural immunology MeSH
- Cytotoxicity, Immunologic MeSH
- Immunity MeSH
- Colorectal Neoplasms etiology immunology pathology MeSH
- Rats MeSH
- Disease Models, Animal MeSH
- CD4-CD8 Ratio MeSH
- Rats, Wistar MeSH
- Receptors, Antigen, T-Cell, gamma-delta analysis MeSH
- T-Lymphocyte Subsets immunology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Receptors, Antigen, T-Cell, gamma-delta MeSH
Tumor development is modulated by the interplay between the transformed cells and the host, and produces changes in the immune system. We followed the cancer progression and the variation of immune parameters in a rat in vivo model of induced colorectal carcinoma. Retrospective data collected from different experiments illustrated the dynamics of the tumor development, and of the immune cells (NK, NKT, T, CD4+, CTL, B and gammadeltaTCR+ cells), cytotoxicity, and CD4/CD8 ratio, at the third, sixth and eighth month of carcinogenesis. The chemically-induced carcinogenesis involved the complete large bowel, with progressive generation of multiple tumors during the complete considered period. Reduction in number and function of cytotoxic and regulatory cells of the innate immunity were crucial for cancer progression.
Spontaneous and Induced Tumors in Germ-Free Animals: A General Review
