Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
15980006
DOI
10.1093/humrep/dei122
PII: dei122
Knihovny.cz E-zdroje
- MeSH
- aneuploidie MeSH
- biologické markery MeSH
- časové faktory MeSH
- chromatin chemie účinky léků metabolismus patologie MeSH
- DNA účinky léků MeSH
- dospělí MeSH
- fragmentace DNA * MeSH
- kohortové studie MeSH
- kovy MeSH
- látky znečišťující vzduch * MeSH
- lidé MeSH
- mužská infertilita etiologie MeSH
- počet spermií MeSH
- průzkumy a dotazníky MeSH
- samovolný potrat MeSH
- sperma účinky léků metabolismus MeSH
- spermie účinky léků metabolismus patologie MeSH
- statistické modely MeSH
- vystavení vlivu životního prostředí * MeSH
- znečištění ovzduší * MeSH
- znečištění tabákovým kouřem * MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- biologické markery MeSH
- chromatin MeSH
- DNA MeSH
- kovy MeSH
- látky znečišťující vzduch * MeSH
- znečištění tabákovým kouřem * MeSH
BACKGROUND: This study examined potential associations between exposure to episodes of air pollution and alterations in semen quality. The air pollution, resulting from combustion of coal for industry and home heating in the Teplice district of the Czech Republic, was much higher during the winter than at other times of year with peaks exceeding US air quality standards. METHODS: Young men from Teplice were sampled up to seven times over 2 years allowing evaluation of semen quality after periods of exposure to both low and high air pollution. Routine semen analysis (sperm concentration, motility and morphology) and tests for sperm aneuploidy and chromatin integrity were performed, comparing measurements within each subject. Exposure was classified as high or low based on data from ambient air pollution monitoring. RESULTS: Using repeated measures analysis, a significant association was found between exposure to periods of high air pollution (at or above the upper limit of US air quality standards) and the percentage of sperm with DNA fragmentation according to sperm chromatin structure assay (SCSA). Other semen measures were not associated with air pollution. CONCLUSION: Exposure to intermittent air pollution may result in sperm DNA damage and thereby increase the rates of male-mediated infertility, miscarriage, and other adverse reproductive outcomes.
Citace poskytuje Crossref.org
Impact of Air Pollution on the Health of the Population in Parts of the Czech Republic
