Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15980006
DOI
10.1093/humrep/dei122
PII: dei122
Knihovny.cz E-resources
- MeSH
- Aneuploidy MeSH
- Biomarkers MeSH
- Time Factors MeSH
- Chromatin chemistry drug effects metabolism pathology MeSH
- DNA drug effects MeSH
- Adult MeSH
- DNA Fragmentation * MeSH
- Cohort Studies MeSH
- Metals MeSH
- Air Pollutants * MeSH
- Humans MeSH
- Infertility, Male etiology MeSH
- Sperm Count MeSH
- Surveys and Questionnaires MeSH
- Abortion, Spontaneous MeSH
- Semen drug effects metabolism MeSH
- Spermatozoa drug effects metabolism pathology MeSH
- Models, Statistical MeSH
- Environmental Exposure * MeSH
- Air Pollution * MeSH
- Tobacco Smoke Pollution * MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers MeSH
- Chromatin MeSH
- DNA MeSH
- Metals MeSH
- Air Pollutants * MeSH
- Tobacco Smoke Pollution * MeSH
BACKGROUND: This study examined potential associations between exposure to episodes of air pollution and alterations in semen quality. The air pollution, resulting from combustion of coal for industry and home heating in the Teplice district of the Czech Republic, was much higher during the winter than at other times of year with peaks exceeding US air quality standards. METHODS: Young men from Teplice were sampled up to seven times over 2 years allowing evaluation of semen quality after periods of exposure to both low and high air pollution. Routine semen analysis (sperm concentration, motility and morphology) and tests for sperm aneuploidy and chromatin integrity were performed, comparing measurements within each subject. Exposure was classified as high or low based on data from ambient air pollution monitoring. RESULTS: Using repeated measures analysis, a significant association was found between exposure to periods of high air pollution (at or above the upper limit of US air quality standards) and the percentage of sperm with DNA fragmentation according to sperm chromatin structure assay (SCSA). Other semen measures were not associated with air pollution. CONCLUSION: Exposure to intermittent air pollution may result in sperm DNA damage and thereby increase the rates of male-mediated infertility, miscarriage, and other adverse reproductive outcomes.
References provided by Crossref.org
Impact of Air Pollution on the Health of the Population in Parts of the Czech Republic
