• This record comes from PubMed

Evidence for hippocampal role in place avoidance other than merely memory storage

. 2006 ; 55 (4) : 445-452. [epub] 20051017

Language English Country Czech Republic Media print-electronic

Document type Journal Article, Research Support, Non-U.S. Gov't

Spatial navigation is used as a popular animal model of higher cognitive functions in people. The data suggest that the hippocampus is important for both storing spatial memories and for performing spatial computations necessary for navigation. Animals use multiple behavioral strategies to solve spatial tasks often using multiple memory systems. We investigated how inactivation of the rat hippocampus affects performance in a place avoidance task to determine if the role of the hippocampus in this task could be attributed to memory storage/retrieval or to the computations needed for navigation. Injecting tetrodotoxin (TTX) into both hippocampi impaired conditioned place avoidance, but after injecting only one hippocampus, the rats learned the place avoidance as well as without any injections. Retention of the place avoidance learned with one hippocampus was not impaired when the injection was switched to the hippocampus that had not been injected during learning. The result suggests that during learning, the hippocampus did not store the place avoidance memory.

References provided by Crossref.org

Newest 20 citations...

See more in
Medvik | PubMed

Genetic modulation of protein expression in rat brain

. 2025 Mar 21 ; 28 (3) : 112079. [epub] 20250221

Transient Inactivation of the Medial Prefrontal Cortex and Ventral Hippocampus Impairs Active Place Avoidance Retrieval on a Rotating Arena

. 2021 ; 15 () : 634533. [epub] 20210428

Chronic MK-801 Application in Adolescence and Early Adulthood: A Spatial Working Memory Deficit in Adult Long-Evans Rats But No Changes in the Hippocampal NMDA Receptor Subunits

. 2018 ; 9 () : 42. [epub] 20180212

Drugs Interfering with Muscarinic Acetylcholine Receptors and Their Effects on Place Navigation

. 2017 ; 8 () : 215. [epub] 20171109

Temporal and spatial strategies in an active place avoidance task on Carousel: a study of effects of stability of arena rotation speed in rats

. 2015 ; 3 () : e1257. [epub] 20150922

Functional inactivation of the rat hippocampus disrupts avoidance of a moving object

. 2011 Mar 29 ; 108 (13) : 5414-8. [epub] 20110314

Stress-induced out-of-context activation of memory

. 2010 Dec 21 ; 8 (12) : e1000570. [epub] 20101221

Find record

Citation metrics

Loading data ...

Archiving options

Loading data ...