Evidence for hippocampal role in place avoidance other than merely memory storage
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16238464
DOI
10.33549/physiolres.930820
PII: 820
Knihovny.cz E-resources
- MeSH
- Anesthetics, Local pharmacology MeSH
- Electroshock MeSH
- Hippocampus physiology MeSH
- Rats MeSH
- Memory drug effects physiology MeSH
- Rats, Long-Evans MeSH
- Feeding Behavior drug effects physiology MeSH
- Tetrodotoxin pharmacology MeSH
- Avoidance Learning drug effects physiology MeSH
- Space Perception drug effects physiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anesthetics, Local MeSH
- Tetrodotoxin MeSH
Spatial navigation is used as a popular animal model of higher cognitive functions in people. The data suggest that the hippocampus is important for both storing spatial memories and for performing spatial computations necessary for navigation. Animals use multiple behavioral strategies to solve spatial tasks often using multiple memory systems. We investigated how inactivation of the rat hippocampus affects performance in a place avoidance task to determine if the role of the hippocampus in this task could be attributed to memory storage/retrieval or to the computations needed for navigation. Injecting tetrodotoxin (TTX) into both hippocampi impaired conditioned place avoidance, but after injecting only one hippocampus, the rats learned the place avoidance as well as without any injections. Retention of the place avoidance learned with one hippocampus was not impaired when the injection was switched to the hippocampus that had not been injected during learning. The result suggests that during learning, the hippocampus did not store the place avoidance memory.
References provided by Crossref.org
Drugs Interfering with Muscarinic Acetylcholine Receptors and Their Effects on Place Navigation
Functional inactivation of the rat hippocampus disrupts avoidance of a moving object
Stress-induced out-of-context activation of memory
