Chemotherapy based on HPMA copolymer conjugates with pH-controlled release of doxorubicin triggers anti-tumor immunity
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16269198
DOI
10.1016/j.jconrel.2005.09.028
PII: S0168-3659(05)00505-5
Knihovny.cz E-resources
- MeSH
- Acrylamides chemical synthesis pharmacology MeSH
- Doxorubicin analogs & derivatives chemical synthesis pharmacology MeSH
- Neoplasms, Experimental immunology prevention & control MeSH
- Galactosamine chemical synthesis pharmacology MeSH
- Immunotherapy, Adoptive * MeSH
- Inhibitory Concentration 50 MeSH
- Injections, Subcutaneous MeSH
- Hydrogen-Ion Concentration MeSH
- Polymethacrylic Acids chemical synthesis pharmacology MeSH
- Delayed-Action Preparations MeSH
- Humans MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Cell Line, Tumor MeSH
- Cell Proliferation drug effects MeSH
- Antineoplastic Agents chemical synthesis pharmacology MeSH
- Spleen cytology immunology transplantation MeSH
- Neoplasm Transplantation MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Acrylamides MeSH
- doxorubicin-N-(2-hydroxypropyl)methacrylamide copolymer conjugate MeSH Browser
- Doxorubicin MeSH
- Galactosamine MeSH
- HPMA coploymer-doxorubicin-galactosamine MeSH Browser
- Polymethacrylic Acids MeSH
- Delayed-Action Preparations MeSH
- Antineoplastic Agents MeSH
A novel class of anti-cancer therapeutics - polymeric conjugates of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers and doxorubicin with pH-controlled release of the drug - is highly efficient in killing tumor cells in vitro and is potent in eradicating growing tumors in vivo. Moreover, in comparison with low-molecular-weight drugs, the macromolecular therapeutics show decreased acute as well as delayed adverse side-toxicity. More importantly, the polymeric conjugates trigger the onset of specific anti-tumor immune response and this anti-tumor immunity can be transferred with splenocytes to naïve recipients. In other terms, chemotherapy based on conjugates of HPMA copolymer with doxorubicin possesses immunomodulating properties. This finding might also have wider implications for the management of relapsing tumors in human patients.
References provided by Crossref.org
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