Effect of silymarin and its polyphenolic fraction on cholesterol absorption in rats
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16275123
DOI
10.1016/j.phrs.2005.09.004
PII: S1043-6618(05)00162-3
Knihovny.cz E-resources
- MeSH
- Antioxidants pharmacology MeSH
- Azetidines pharmacology MeSH
- Cholesterol, Dietary pharmacokinetics MeSH
- Cholestyramine Resin pharmacology MeSH
- Ezetimibe MeSH
- Phenols pharmacology MeSH
- Flavonoids pharmacology MeSH
- Intestinal Absorption drug effects MeSH
- Liver drug effects metabolism MeSH
- Rats MeSH
- Lipoproteins, VLDL blood MeSH
- Lipoproteins metabolism MeSH
- Polyphenols MeSH
- Silymarin pharmacology MeSH
- Triglycerides pharmacology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antioxidants MeSH
- Azetidines MeSH
- Cholesterol, Dietary MeSH
- Cholestyramine Resin MeSH
- Ezetimibe MeSH
- Phenols MeSH
- Flavonoids MeSH
- Lipoproteins, VLDL MeSH
- Lipoproteins MeSH
- Polyphenols MeSH
- Silymarin MeSH
- Triglycerides MeSH
This study evaluated the influence of silymarin (SM) and polyphenolic fraction (PF) of silymarin on cholesterol absorption in rats fed on high cholesterol diet (HCD). HCD induced a remarkable increase in hepatic, plasma, VLDL and LDL cholesterol, a decrease in HDL cholesterol and an elevation in triacylglycerol (TAG) levels in plasma, VLDL and in the liver. SM and PF were administered as dietary supplements (1.0%) in HCD for 18 days. Intestinal cholesterol absorption was measured by dual-isotope plasma ratio method, which calculates percent of cholesterol absorption from the ratio of two labelled cholesterol doses, one given intragastrically (14C) and one intravenously (3H). Silymarin and PF significantly reduced cholesterol absorption in rats fed on HCD and caused significant decreases in plasma and VLDL cholesterol and content of cholesterol and TAG in the liver. The level of HDL cholesterol was significantly increased after silymarin, but not after administration of PF. The levels of TAG in plasma and VLDL were not affected by either silymarin or PF. These results suggest that the inhibition of cholesterol absorption caused by silymarin and its polyphenolic fraction could be a mechanism contributing to the positive changes in plasma cholesterol lipoprotein profile and in lipid content in liver.
References provided by Crossref.org
