TP53 gene mutations are rare in nondysplastic Barrett's esophagus
Language English Country United States Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Adenocarcinoma genetics pathology MeSH
- Barrett Esophagus genetics pathology MeSH
- Biopsy MeSH
- DNA genetics MeSH
- Adult MeSH
- Exons MeSH
- Genetic Markers MeSH
- Genes, p53 genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Mutation * MeSH
- Esophageal Neoplasms genetics pathology MeSH
- Polymerase Chain Reaction MeSH
- Precancerous Conditions genetics pathology MeSH
- Disease Progression MeSH
- Retrospective Studies MeSH
- Risk Factors MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- DNA MeSH
- Genetic Markers MeSH
In search of potential prognostic markers, we analyzed a large series of tissues of Barrett's esophagus and samples of adenocarcinomas arising in the terrain of Barrett's esophagus for TP53 gene mutations by direct sequencing of exons 5 to 9 of the TP53 gene. While 9 of 21 adenocarcinomas tested (42.9%) contained a TP53 mutation, none of 24 samples from Barrett's esophagus were mutated. This observation suggests that TP53 gene mutation may be a relatively late event in the progression from nondysplastic Barrett's esophagus to adenocarcinoma of esophagus. Therefore, TP53 gene mutations alone are not likely to represent a widely useful prognostic marker of the risk of progression to malignancy, at least not in Barrett's esophagus without dysplasia.
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