The influence of mild hypothermia on ICP, CPP and outcome in patients with primary and secondary brain injury
Language English Country Austria Media print
Document type Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
- MeSH
- Adult MeSH
- Risk Assessment methods MeSH
- Outcome Assessment, Health Care MeSH
- Incidence MeSH
- Intracranial Hypertension mortality therapy MeSH
- Intracranial Pressure * MeSH
- Comorbidity MeSH
- Blood Pressure * MeSH
- Quality of Life MeSH
- Humans MeSH
- Manometry methods statistics & numerical data MeSH
- Survival Rate MeSH
- Recovery of Function MeSH
- Pilot Projects MeSH
- Brain Injuries mortality therapy MeSH
- Prognosis MeSH
- Risk Factors MeSH
- Hypothermia, Induced methods statistics & numerical data MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
- Geographicals
- Czech Republic epidemiology MeSH
Aim of this study was to examine the hypothesis that only a subgroup of patients with lesser primary brain damage after severe head injury may benefit from therapeutic hypothermia. We prospectively analysed 72 patients with severe head injury, randomized into groups with (n = 37) and without (n = 35) hypothermia of 34 degrees C maintained for 72 hours. The influence of hypothermia on ICP, CPP and neurological outcome was analysed in the context of the extent of primary brain damage. Patients with normothermia and primary lesions (n = 17) values: GCS on admission 5 (median), ICP 18.9 (mean), CPP 73 (mean), GOS 4 (median). Patients with normothermia and extracerebral hematomas (n = 20): GCS 4, ICP 16, CPP 71, GOS 3. Patients with hypothermia and primary lesions (n = 21): GCS 4,62, ICP 10, 81, CPP 78,1, GOS 4. Patients with hypothermia and extracerebral hematomas (n = 14): GCS 5, ICP 13.2, CPP 78, GOS 5. Hypothermia decreased ICP and increased CPP regardless of the type of brain injury. Hypothermia was not able to improve outcome in patients with primary brain lesions but this pilot study suggests that it significantly improves outcome in patients with extracerebral hematomas.
References provided by Crossref.org