Analysis of sensitivity to MK-801 treatment in a novel active allothetic place avoidance task and in the working memory version of the Morris water maze reveals differences between Long-Evans and Wistar rats
Language English Country Ireland Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
16712995
DOI
10.1016/j.neures.2006.04.007
PII: S0168-0102(06)00091-5
Knihovny.cz E-resources
- MeSH
- Excitatory Amino Acid Antagonists pharmacology MeSH
- Maze Learning drug effects physiology MeSH
- Dizocilpine Maleate pharmacology MeSH
- Species Specificity MeSH
- Receptors, Glutamate drug effects metabolism MeSH
- Hyperkinesis chemically induced physiopathology MeSH
- Memory, Short-Term drug effects physiology MeSH
- Rats MeSH
- Glutamic Acid metabolism MeSH
- Disease Models, Animal MeSH
- Brain drug effects physiology MeSH
- Synaptic Transmission drug effects physiology MeSH
- Orientation drug effects physiology MeSH
- Memory Disorders chemically induced physiopathology MeSH
- Rats, Long-Evans MeSH
- Rats, Wistar MeSH
- Avoidance Learning drug effects physiology MeSH
- Space Perception drug effects physiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Excitatory Amino Acid Antagonists MeSH
- Dizocilpine Maleate MeSH
- Receptors, Glutamate MeSH
- Glutamic Acid MeSH
The aims of the present study were to compare the effect of subchronic administration of MK-801 on performance in the active allothetic place avoidance (AAPA) task and in the working version of Morris water maze (MWM) in Long-Evans and Wistar rats. Animals were trained for four daily sessions either in the AAPA or in the working memory version of the MWM. Wistar rats treated by MK-801 (0.1 mg/kg) showed a cognitive deficit in the AAPA task without a significant hyperlocomotion, whereas they were not impaired in the working memory version of the MWM compared to controls. Long-Evans rats treated by MK-801 (0.1 mg/kg) were not impaired either in the AAPA task or in the MWM task. Higher doses of MK-801 (0.2 and 0.3 mg/kg) produced hyperlocomotion in both strains which corresponded to an inability to solve both spatial tasks. Long-Evans rats were superior in the MWM to the Wistar rats in the groups treated with the low dose of MK-801. In conclusion, intact Wistar rats can efficiently solve both spatial tasks; however, they are more sensitive to MK-801-induced behavioural deficit. This has relevance for modeling of the schizophrenia-related deficits and for screening substances for their therapeutic potential.
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