Oncocytic papillary renal cell carcinoma: a clinicopathologic, immunohistochemical, ultrastructural, and interphase cytogenetic study of 12 cases
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu kazuistiky, časopisecké články
PubMed
16730306
DOI
10.1016/j.anndiagpath.2005.12.002
PII: S1092-9134(05)00209-1
Knihovny.cz E-zdroje
- MeSH
- aneuploidie MeSH
- chromozomální delece MeSH
- cytoplazma ultrastruktura MeSH
- diferenciální diagnóza MeSH
- dospělí MeSH
- hybridizace in situ fluorescenční MeSH
- interfáze genetika MeSH
- karcinom z renálních buněk chemie genetika patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- lidské chromozomy, pár 17 MeSH
- lidské chromozomy, pár 7 MeSH
- lidský chromozom Y genetika MeSH
- nádorové biomarkery analýza MeSH
- nádory ledvin chemie genetika patologie MeSH
- oxyfilní adenom diagnóza MeSH
- oxyfilní buňky patologie MeSH
- papilární karcinom chemie genetika patologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- Názvy látek
- nádorové biomarkery MeSH
Papillary renal cell carcinoma (RCC) is subclassified in type 1 displaying cells with scanty pale cytoplasm arranged in a single layer and in type 2 showing pseudostratified cells with eosinophilic cytoplasm. However, the existence of more variants of papillary RCC may be inferred by the recognition of few cases with different morphological features. We report the clinicopathologic, immunohistochemical, ultrastructural, and interphase cytogenetic features of 12 papillary RCC composed by oncocytes. Ten patients were males and their median age was 67 years. The tumors were well demarcated and their median diameter was 7.1 cm. Solid oncocytoma-like areas occurred in 11 cases. The cytoplasm of the neoplastic cells was filled by mitochondria with lamellar cristae. All cases were positive for the antimitochondrial antigen and racemase and showed variable immunoreactivity for cytokeratins (AE1/AE3, CK8-18, CK7, CK19), EMA, CD10, vimentin, and parvalbumin. MIB1 was detected in 0 to 6 cells per 1 high-power field. Fluorescent in situ hybridization analysis on formalin-fixed paraffin-embedded tissue showed three or more signals for chromosome 7 and 17 (for both > or =30% of nuclei in 7 of 12 neoplasms). In males, signals of chromosome Y were absent in more than 80% of the neoplastic nuclei. One patient died of metastases. Interphase cytogenetic analysis by fluorescent in situ hybridization can be a diagnostic tool in cases mimicking an oncocytoma.
Citace poskytuje Crossref.org
Molecular Genetics of Renal Cell Tumors: A Practical Diagnostic Approach
Typical signs of oncocytic papillary renal cell carcinoma in everyday clinical praxis