Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological, immunohistochemical and genetic features
Language English Country Germany Media print
Document type Journal Article
- MeSH
- Biomarkers analysis MeSH
- Diagnosis, Differential MeSH
- Genome, Human MeSH
- In Situ Hybridization, Fluorescence MeSH
- Nucleic Acid Hybridization MeSH
- Immunohistochemistry MeSH
- Keratins analysis MeSH
- Kidney blood supply metabolism pathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Mucin-1 analysis MeSH
- Mutation MeSH
- Von Hippel-Lindau Tumor Suppressor Protein genetics MeSH
- Kidney Neoplasms genetics metabolism pathology MeSH
- Adenoma, Oxyphilic genetics metabolism pathology MeSH
- Parvalbumins analysis MeSH
- Caenorhabditis elegans Proteins MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Vacuolar Proton-Translocating ATPases MeSH
- Loss of Heterozygosity MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Biomarkers MeSH
- CAM 5.2 antigen MeSH Browser
- Keratins MeSH
- Mucin-1 MeSH
- Von Hippel-Lindau Tumor Suppressor Protein MeSH
- Parvalbumins MeSH
- Caenorhabditis elegans Proteins MeSH
- Vacuolar Proton-Translocating ATPases MeSH
- VHA-5 protein, C elegans MeSH Browser
- VHL protein, human MeSH Browser
We attempted to investigate the clinicopathological correlation of renal oncocytoma (RO) with renal vein extension. We identified seven ROs with extension into the branches of renal vein. The age of seven patients ranged from 61 to 82 years. Five cases were identified; incidentally, two patients had gross hematuria. After surgery, all patients were alive and free of tumors with follow-up of 1 to 5 years (mean=3.6). Oncocytomas measured from 2.2 to 7.5 cm. Renal vein extension was grossly suspected in 5/7 cases and histologically confirmed in all seven cases. Tumor cells were positive for cytokeratins, mitochondrial antigen, epithelial membrane antigen, and parvalbumin; 5/7 tumors were focally positive for cluster of differentiation 117. Ultrastructurally, the cytoplasm was packed by mitochondria. Molecular genetic analysis did not detect abnormal numbers of chromosomes 1, 2, 6, 7, 10, 17, and XY by fluorescence in situ hybridization, loss of heterozygosity on 3p, and mutation of Von Hippel-Lindau gene in all cases. Array comparative genomic hybridization analysis of two cases did not show any major genetic changes. Conclusions are: (1) renal oncocytomas may have intravascular extension to the branches of the renal vein; (2) renal oncocytomas with intravascular extension to the branches of the renal vein have the same morphological, immunohistochemical, and cytogenetic findings as have their counterparts without evidence of intravascular invasion; (3) the absence of metastases suggests an overall benign behavior of this tumor, but this has to be substantiated by further studies with a long-term follow-up; (4) in a renal tumor with granular cytoplasm showing renal vein extension, it is necessary to carefully exclude renal cell carcinomas (RCC) such as chromophobe RCC, oncocytic variant of papillary RCC, and granular variant of clear cell RCC.
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Am J Surg Pathol. 1997 Aug;21(8):871-83 PubMed
Arch Pathol Lab Med. 2002 May;126(5):610-2 PubMed
J Pathol. 1997 Oct;183(2):131-3 PubMed
J Urol. 1988 Mar;139(3):585-7 PubMed
Br J Urol. 1988 Jul;62(1):89-90 PubMed
Br J Urol. 1996 Jun;77(6):927-8 PubMed
Cancer. 1997 Sep 1;80(5):987-9 PubMed
Mod Pathol. 2005 Feb;18(2):161-9 PubMed
Am J Surg Pathol. 2005 Dec;29(12):1576-81 PubMed
Semin Diagn Pathol. 1998 Feb;15(1):21-40 PubMed
Am J Surg Pathol. 1999 Jul;23(7):772-80 PubMed
Am J Surg Pathol. 2002 Mar;26(3):281-91 PubMed
Am J Surg Pathol. 1997 Jan;21(1):1-12 PubMed
J Urol. 2006 Jun;175(6):2302-6 PubMed
J Comput Assist Tomogr. 1986 Nov-Dec;10 (6):1054-6 PubMed
Adv Anat Pathol. 1999 Jan;6(1):1-11 PubMed
Ann Diagn Pathol. 2006 Jun;10(3):133-9 PubMed
