Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological, immunohistochemical and genetic features
Jazyk angličtina Země Německo Médium print
Typ dokumentu časopisecké články
- MeSH
- biologické markery analýza MeSH
- diferenciální diagnóza MeSH
- genom lidský MeSH
- hybridizace in situ fluorescenční MeSH
- hybridizace nukleových kyselin MeSH
- imunohistochemie MeSH
- keratiny analýza MeSH
- ledviny krevní zásobení metabolismus patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mucin 1 analýza MeSH
- mutace MeSH
- nádorový supresorový protein VHL genetika MeSH
- nádory ledvin genetika metabolismus patologie MeSH
- oxyfilní adenom genetika metabolismus patologie MeSH
- parvalbuminy analýza MeSH
- proteiny Caenorhabditis elegans MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- vakuolární protonové ATPasy MeSH
- ztráta heterozygozity MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- biologické markery MeSH
- CAM 5.2 antigen MeSH Prohlížeč
- keratiny MeSH
- mucin 1 MeSH
- nádorový supresorový protein VHL MeSH
- parvalbuminy MeSH
- proteiny Caenorhabditis elegans MeSH
- vakuolární protonové ATPasy MeSH
- VHA-5 protein, C elegans MeSH Prohlížeč
- VHL protein, human MeSH Prohlížeč
We attempted to investigate the clinicopathological correlation of renal oncocytoma (RO) with renal vein extension. We identified seven ROs with extension into the branches of renal vein. The age of seven patients ranged from 61 to 82 years. Five cases were identified; incidentally, two patients had gross hematuria. After surgery, all patients were alive and free of tumors with follow-up of 1 to 5 years (mean=3.6). Oncocytomas measured from 2.2 to 7.5 cm. Renal vein extension was grossly suspected in 5/7 cases and histologically confirmed in all seven cases. Tumor cells were positive for cytokeratins, mitochondrial antigen, epithelial membrane antigen, and parvalbumin; 5/7 tumors were focally positive for cluster of differentiation 117. Ultrastructurally, the cytoplasm was packed by mitochondria. Molecular genetic analysis did not detect abnormal numbers of chromosomes 1, 2, 6, 7, 10, 17, and XY by fluorescence in situ hybridization, loss of heterozygosity on 3p, and mutation of Von Hippel-Lindau gene in all cases. Array comparative genomic hybridization analysis of two cases did not show any major genetic changes. Conclusions are: (1) renal oncocytomas may have intravascular extension to the branches of the renal vein; (2) renal oncocytomas with intravascular extension to the branches of the renal vein have the same morphological, immunohistochemical, and cytogenetic findings as have their counterparts without evidence of intravascular invasion; (3) the absence of metastases suggests an overall benign behavior of this tumor, but this has to be substantiated by further studies with a long-term follow-up; (4) in a renal tumor with granular cytoplasm showing renal vein extension, it is necessary to carefully exclude renal cell carcinomas (RCC) such as chromophobe RCC, oncocytic variant of papillary RCC, and granular variant of clear cell RCC.
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