The effect of repetitive transcranial magnetic stimulation (rTMS) on symptoms in obsessive compulsive disorder. A randomized, double blind, sham controlled study
Language English Country Sweden Media print
Document type Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
PubMed
16816829
PII: NEL270306A15
Knihovny.cz E-resources
- MeSH
- Antidepressive Agents, Second-Generation therapeutic use MeSH
- Adult MeSH
- Double-Blind Method MeSH
- Electric Stimulation Therapy methods MeSH
- Combined Modality Therapy MeSH
- Drug Resistance MeSH
- Humans MeSH
- Statistics, Nonparametric MeSH
- Neuropsychological Tests MeSH
- Obsessive-Compulsive Disorder therapy MeSH
- Paroxetine therapeutic use MeSH
- Prefrontal Cortex drug effects physiopathology MeSH
- Selective Serotonin Reuptake Inhibitors therapeutic use MeSH
- Severity of Illness Index MeSH
- Transcranial Magnetic Stimulation * MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
- Names of Substances
- Antidepressive Agents, Second-Generation MeSH
- Paroxetine MeSH
- Serotonin Uptake Inhibitors MeSH
BACKGROUND: The goal of our study is to assess whether transcranial magnetic stimulation (rTMS) would facilitate the effect of antidepressant in OCD patients. METHOD: The aim of the randomized, double-blind, sham controlled study was to compare the 2 and 4 week efficacy of the 10 sessions rTMS with sham rTMS in serotonin reuptake inhibitor resistant OCD patient. Thirty three right-handed patients were randomly assigned to either active rTMS or to sham rTMS. Active rTMS with the frequency of 1 Hz at 110% of motor threshold (MT) was administered over the left dorso-lateral prefrontal cortex. The same time schedule was used for sham administration. Thirty patients finished the study, three patients' dropped out at the beginning. Psychopathology was assessed by CGI, HAMA, Y-BOCS and BAI before the treatment, immediately after the experimental treatment, and 2 weeks after the experimental treatment by an independent reviewer. RESULTS: Both groups improved during the study period but the treatment effect did not differ between them in any of the instruments. CONCLUSION: Low frequency rTMS administered over the left dorso-lateral prefrontal cortex during 10 daily sessions did not differ from sham rTMS in facilitating the effect of serotonin reuptake inhibitors in OCD patients.
Towards causal mechanisms of consciousness through focused transcranial brain stimulation
Cognitive behavioral therapy in pharmacoresistant obsessive-compulsive disorder
