Occurrence of aminoglycoside-modifying-enzyme genes aac(6')-aph(2"), aph(3'), ant(4') and ant(6) in clinical isolates of Enterococcus faecalis resistant to high-level of gentamicin and amikacin
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16821713
DOI
10.1007/bf02931451
Knihovny.cz E-resources
- MeSH
- Acetyltransferases genetics MeSH
- Amikacin pharmacology MeSH
- Aminoglycosides pharmacology MeSH
- Anti-Bacterial Agents pharmacology MeSH
- DNA, Bacterial analysis genetics MeSH
- Enterococcus faecalis drug effects enzymology genetics isolation & purification MeSH
- Phosphotransferases (Alcohol Group Acceptor) genetics MeSH
- Gentamicins pharmacology MeSH
- Gram-Positive Bacterial Infections microbiology MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Drug Resistance, Multiple, Bacterial genetics MeSH
- Nucleotidyltransferases genetics MeSH
- Polymerase Chain Reaction MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 6'-aminoglycoside acetyltransferase-2''-aminoglycoside phosphotransferase MeSH Browser
- Acetyltransferases MeSH
- Amikacin MeSH
- Aminoglycosides MeSH
- Anti-Bacterial Agents MeSH
- DNA, Bacterial MeSH
- Phosphotransferases (Alcohol Group Acceptor) MeSH
- Gentamicins MeSH
- Nucleotidyltransferases MeSH
- streptomycin 3''-kinase MeSH Browser
The genes coding for 4 aminoglycoside-modifying enzymes AAC(6')-APH(2"), APH(3'), ANT(4') and ANT(6) were determined in 44 Slovak clinical isolates of Enterococcus faecalis with high-level resistance to gentamicin (HLGR, collection 1) and 48 E. faecalis isolates with resistance to amikacin (AR, collection 2). The occurrence of spotted genes was (collection 1 vs. collection 2): aac(6)-aph(2") 81.8 vs. 8.3 %, ant(4') 52.3 vs. 81.3 %, aph(3') 50 vs. 56.3 % and ant(6) 6.8 vs. 4.2 %, the most frequent combinations of genes in the HLGR collection were aac(6')-aph(2") + ant(4') and aac(6')-aph(2") + aph(3). In contrast, the aph(3') + ant(4') gene profile was predominant in AR isolates. None of the isolates contained all four AGME genes simultaneously.
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