Changes of collagen metabolism predict the left ventricular remodeling after myocardial infarction
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- biologické markery krev metabolismus MeSH
- časové faktory MeSH
- echokardiografie MeSH
- funkce levé komory srdeční MeSH
- infarkt myokardu metabolismus MeSH
- kolagen typu I MeSH
- kolagen metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- peptidové fragmenty krev metabolismus MeSH
- peptidy MeSH
- prokolagen krev metabolismus MeSH
- remodelace komor fyziologie MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- biologické markery MeSH
- collagen type I trimeric cross-linked peptide MeSH Prohlížeč
- kolagen typu I MeSH
- kolagen MeSH
- peptidové fragmenty MeSH
- peptidy MeSH
- procollagen type I carboxy terminal peptide MeSH Prohlížeč
- procollagen Type III-N-terminal peptide MeSH Prohlížeč
- prokolagen MeSH
OBJECTIVES: To analyze the predictive value of cardiac collagen metabolism "in vivo" in patients with myocardial infarction (MI) treated with percutaneous coronary intervention (PCI). DESIGN: Forty-five patients (age 66 +/- 8.27) underwent biochemical analysis for cardiac collagen metabolism (groups A, B and C); 30 patients with their first MI were treated with successful PCI (group A; n = 30), group B (n = 5) were MI patients with unsuccessful PCI. Group C were patients without MI (n = 10), they underwent elective diagnostic coronary angiography only. The collagen metabolism was analyzed in acute and subacute MI phases by using serum blood markers: the carboxy-terminal propeptide of type I procollagen (PICP), amino-terminal propeptide of type III procollagen (PIIINP) and carboxy-terminal telopeptide of type I collagen (ICTP). Furthermore, the ejection fraction (EF) and left ventricular end-diastolic volume maximal changes in the course of 6 months were measured by echocardiography. RESULTS: A significant increase of both PICP and PIIINP on day 4 following MI was detected. Furthermore, PICP and PIIINP level assessed on the 30th day was significantly higher in the PCI unsuccessful group versus successful group. PICP level on day 4 above 110 microg/l and PIIINP level above 4 microg/l was significantly often found in the subgroup of patients with the EF improvement less than 10% or worsening and with significant left ventricular dilatation during 6 months follow-up. Cardiac catheterization itself does not affect collagen metabolism. CONCLUSION: We concluded that collagen metabolism markers enable to study in vivo the MI healing and to predict left ventricular functional and volume changes.
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