Changes of collagen metabolism predict the left ventricular remodeling after myocardial infarction
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Biomarkers blood metabolism MeSH
- Time Factors MeSH
- Echocardiography MeSH
- Ventricular Function, Left MeSH
- Myocardial Infarction metabolism MeSH
- Collagen Type I MeSH
- Collagen metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Peptide Fragments blood metabolism MeSH
- Peptides MeSH
- Procollagen blood metabolism MeSH
- Ventricular Remodeling physiology MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers MeSH
- collagen type I trimeric cross-linked peptide MeSH Browser
- Collagen Type I MeSH
- Collagen MeSH
- Peptide Fragments MeSH
- Peptides MeSH
- procollagen type I carboxy terminal peptide MeSH Browser
- procollagen Type III-N-terminal peptide MeSH Browser
- Procollagen MeSH
OBJECTIVES: To analyze the predictive value of cardiac collagen metabolism "in vivo" in patients with myocardial infarction (MI) treated with percutaneous coronary intervention (PCI). DESIGN: Forty-five patients (age 66 +/- 8.27) underwent biochemical analysis for cardiac collagen metabolism (groups A, B and C); 30 patients with their first MI were treated with successful PCI (group A; n = 30), group B (n = 5) were MI patients with unsuccessful PCI. Group C were patients without MI (n = 10), they underwent elective diagnostic coronary angiography only. The collagen metabolism was analyzed in acute and subacute MI phases by using serum blood markers: the carboxy-terminal propeptide of type I procollagen (PICP), amino-terminal propeptide of type III procollagen (PIIINP) and carboxy-terminal telopeptide of type I collagen (ICTP). Furthermore, the ejection fraction (EF) and left ventricular end-diastolic volume maximal changes in the course of 6 months were measured by echocardiography. RESULTS: A significant increase of both PICP and PIIINP on day 4 following MI was detected. Furthermore, PICP and PIIINP level assessed on the 30th day was significantly higher in the PCI unsuccessful group versus successful group. PICP level on day 4 above 110 microg/l and PIIINP level above 4 microg/l was significantly often found in the subgroup of patients with the EF improvement less than 10% or worsening and with significant left ventricular dilatation during 6 months follow-up. Cardiac catheterization itself does not affect collagen metabolism. CONCLUSION: We concluded that collagen metabolism markers enable to study in vivo the MI healing and to predict left ventricular functional and volume changes.
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