Different cell cycle modulation following treatment of human ovarian carcinoma cells with a new platinum(IV) complex vs cisplatin

. 2007 Oct ; 25 (5) : 435-43. [epub] 20070523

Jazyk angličtina Země Spojené státy americké Médium print-electronic

Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/pmid17520175

Platinum (IV) derivative with adamantylamine-LA-12-represents a new generation of highly efficient anti-cancer drug derived from cisplatin and is currently in the final stage of phase I clinical trials. Understanding the specific mechanisms of its effects on cell cycle is necessary for defining the mode of action of LA-12. In this study, we characterized the ability of LA-12 to induce cell cycle perturbations in ovarian cancer cell line A2780 as compared to equitoxic cisplatin treatment. LA-12 induced a permanent accumulation of A2780 cells in S phase while cisplatin caused G2/M arrest at 24-h time point, where we also detected an increased expression of Gadd45alpha protein. Although both derivatives induced a rapid increase of p53 expression, this was not associated with a down-regulation of Mdm2 protein. Increased expression of p21(Cip1/WAF1) protein and its association with cyclins A and B1 suggested that this cyclin-dependent kinase inhibitor might contribute significantly to the observed perturbations of cell cycle. The results of this study provide insight into the mechanism of action of platinum-based derivative with adamantylamine on cell cycle in ovarian cancer cells. The differences between effects of LA-12 and cisplatin suggest that more attention should be paid to elucidation of modes of action of novel platinum(IV) complexes at cellular level.

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Science. 1996 Dec 6;274(5293):1664-72 PubMed

Anticancer Drugs. 2006 Feb;17(2):201-6 PubMed

Mol Cancer Ther. 2002 Oct;1(12):1067-78 PubMed

Cancer Res. 1987 Jan 15;47(2):414-8 PubMed

Cell. 1998 Oct 2;95(1):5-8 PubMed

J Med Chem. 2004 Jan 29;47(3):761-3 PubMed

EMBO J. 1993 Feb;12 (2):461-8 PubMed

Oncogene. 1994 Dec;9(12):3743-51 PubMed

FEBS Lett. 2001 Feb 16;490(3):117-22 PubMed

J Immunol Methods. 1992 Jul 6;151(1-2):237-44 PubMed

Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3706-11 PubMed

Biochem Biophys Res Commun. 1994 Mar 15;199(2):937-43 PubMed

Biochem Pharmacol. 2005 Feb 1;69(3):373-83 PubMed

Semin Oncol. 1984 Sep;11(3):285-98 PubMed

Cell. 1993 Nov 19;75(4):817-25 PubMed

Prog Nucleic Acid Res Mol Biol. 2001;67:93-130 PubMed

Oncogene. 1995 Oct 5;11(7):1217-28 PubMed

Science. 1994 Nov 25;266(5189):1376-80 PubMed

Met Ions Biol Syst. 2004;42:297-322 PubMed

Int J Pharm. 2005 Jan 6;288(1):123-9 PubMed

Methods Find Exp Clin Pharmacol. 2004 Nov;26(9):679-85 PubMed

Cell. 1992 Nov 13;71(4):587-97 PubMed

Nature. 1997 May 15;387(6630):296-9 PubMed

Cancer Invest. 1993;11(3):264-75 PubMed

Eur J Cancer. 1998 Sep;34(10):1535-42 PubMed

Nature. 1993 Dec 16;366(6456):701-4 PubMed

Br J Cancer. 1996 Oct;74(7):1037-45 PubMed

Neoplasma. 2002;49(6):362-7 PubMed

Cell. 1995 Jan 27;80(2):293-9 PubMed

Oncogene. 1999 May 6;18(18):2892-900 PubMed

Trends Cell Biol. 2003 Feb;13(2):65-70 PubMed

J Med. 1993;24(4-5):209-65 PubMed

Cytometry. 1997 Jan 1;27(1):54-64 PubMed

Gynecol Oncol. 2006 Jul;102(1):32-40 PubMed

Expert Rev Anticancer Ther. 2006 Jul;6(7):973-82 PubMed

Chem Rev. 1999 Sep 8;99(9):2451-66 PubMed

Anticancer Drugs. 2004 Jun;15(5):537-43 PubMed

Chem Biol Interact. 1999 Jan 29;117(2):99-115 PubMed

Cancer Res. 1988 Oct 15;48(20):5713-6 PubMed

Prog Cell Cycle Res. 1996;2:165-73 PubMed

Neoplasia. 2000 Jul-Aug;2(4):291-9 PubMed

Oncogene. 2001 Apr 5;20(15):1923-7 PubMed

Anticancer Drugs. 2005 Jul;16(6):653-7 PubMed

Cancer Res. 1988 Dec 1;48(23):6703-7 PubMed

Oncogene. 2003 Oct 20;22(47):7265-79 PubMed

Mol Pharmacol. 2006 Nov;70(5):1708-19 PubMed

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