Interleukin- 1 gene polymorphisms as assessed in a 10-year study of patients with early-onset periodontitis
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
17575917
DOI
10.1007/bf02932157
Knihovny.cz E-resources
- MeSH
- Aggregatibacter actinomycetemcomitans isolation & purification MeSH
- Bacteria isolation & purification MeSH
- Adult MeSH
- Genetic Predisposition to Disease MeSH
- Genotype MeSH
- Interleukin-1 genetics MeSH
- Humans MeSH
- Urban Population MeSH
- Adolescent MeSH
- Oral Hygiene MeSH
- Periodontal Index MeSH
- Periodontitis diagnosis genetics microbiology prevention & control MeSH
- Polymorphism, Genetic MeSH
- Porphyromonas gingivalis isolation & purification MeSH
- Prevotella intermedia isolation & purification MeSH
- Treponema denticola isolation & purification MeSH
- Dental Health Surveys MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic epidemiology MeSH
- Names of Substances
- Interleukin-1 MeSH
Our 10-year study of early-onset periodontitis (EOP) patients includes repeated clinical observations, microbiological characteristics and analysis of genetic polymorphism of IL-1A and IL-1B genes. Twenty patients (age 15-26 years) were divided according to the clinical status in the 4th year into a group with mean number of teeth with bleeding on probing (BP) 9.8 and mean number of teeth with periodontal pocket (PP) 2.23, and a group with mean number of teeth with BP 5.37 and no PP. Significantly higher values of mean BP and PP were found among the groups during the study but a strong progression of disease was found only in 3 patients. The risk IL-1A allele-2 and IL-1B allele-2 genotype and bacterial presence were analyzed by DNA hybridization methods. No significant differences of bacteria composition (Treponema denticola, Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans) were found between the groups. A higher prevalence of composite IL-1 genotype was detected in the group of EOP patients with progressive disease. Early finding of the disease followed by conservative therapy could positively influence the disease progression. EOP treated in early stages may, but need not, develop into the aggressive form in the presence of risk genotype IL-1.
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