Nucleostemin expression in squamous cell carcinoma of the head and neck
Language English Country Greece Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
17970071
Knihovny.cz E-resources
- MeSH
- Cell Nucleolus metabolism MeSH
- Immunohistochemistry MeSH
- Nuclear Proteins biosynthesis MeSH
- Larynx metabolism MeSH
- Humans MeSH
- Biomarkers, Tumor biosynthesis MeSH
- Head and Neck Neoplasms metabolism pathology MeSH
- Oropharynx metabolism MeSH
- GTP-Binding Proteins MeSH
- Carcinoma, Squamous Cell metabolism pathology MeSH
- Carrier Proteins biosynthesis MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- GNL3 protein, human MeSH Browser
- Nuclear Proteins MeSH
- Biomarkers, Tumor MeSH
- GTP-Binding Proteins MeSH
- Carrier Proteins MeSH
BACKGROUND: This study presents initial data on presence of nucleostemin--a nucleolar protein typical of stem cells in the normal squamous epithelium of the oropharynx and larynx - in squamous cell carcinoma originating from these epithelia. MATERIALS AND METHODS: Differentiation and proliferation markers such as keratins, beta-catenin, galectin-1, and Ki-67 were studied in parallel with nucleostemin for defining cell characteristics. RESULTS: Nucleostemin was detected in nucleoli of both proliferating basal cells and terminally differentiated suprabasal cells of normal epithelium and in tumor cells. Importantly, malignant transformation was connected with a significant enlargement of nucleostemin-positive nucleoli in these cell types. CONCLUSION: Detection of nucleostemin in head and neck cancer cells, together with the size of nucleoli, may be important in the evaluation of tumor differentiation and biology.
