Infectivity, pathogenicity, and genetic characteristics of mammalian gastric Cryptosporidium spp. in domestic ruminants
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18343038
DOI
10.1016/j.vetpar.2008.01.033
PII: S0304-4017(08)00073-3
Knihovny.cz E-resources
- MeSH
- Cryptosporidium * genetics pathogenicity MeSH
- Species Specificity MeSH
- Genetic Variation * MeSH
- Genotype MeSH
- Host-Parasite Interactions MeSH
- Cryptosporidiosis parasitology veterinary MeSH
- Rats MeSH
- Animals, Newborn MeSH
- Parasite Egg Count MeSH
- Ruminants parasitology MeSH
- RNA, Protozoan analysis MeSH
- RNA, Ribosomal, 18S analysis MeSH
- Cattle MeSH
- Abomasum parasitology pathology MeSH
- Life Cycle Stages MeSH
- Gastric Mucosa parasitology pathology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Cattle MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- RNA, Protozoan MeSH
- RNA, Ribosomal, 18S MeSH
Farm ruminants were infected experimentally with four mammalian gastric Cryptosporidium, namely Cryptosporidium andersoni LI03 originated from cattle and three isolates of Cryptosporidium muris from brown rat (isolate RN66), Bactrian camel (isolate CB03) and firstly characterized isolate from East African mole rat (isolate TS03). Sequence characterizations of the small-subunit rRNA gene showed that the LI03 isolate was C. andersoni and the other three isolates belonged to C. muris, although the TS03 isolate showed unique sequence variations (one single nucleotide change and four nucleotide insertions). C. andersoni LI03 was infectious for calves only, whereas lambs and kids were susceptible to C. muris CB03. C. muris TS03 and RN66 were not infectious for any farm ruminants. Infection dynamics including prepatent and patent period and infection intensity of the isolates used differed depending on the host species, but no clinical signs of cryptosporidiosis were observed in any of experimentally infected hosts. Cryptosporidium developmental stages were only detected in infected animals in the abomasum region. Histopathological changes were characterized by dilatation and epithelial metaplasia of infected gastric glands with no significant inflammatory responses in the lamina propria.
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