Biotransformation enzymes in development of renal injury and urothelial cancer caused by aristolochic acid
Language English Country United States Media print
Document type Journal Article, Comment
PubMed
18480852
DOI
10.1038/ki.2008.125
PII: S0085-2538(15)52909-8
Knihovny.cz E-resources
- MeSH
- Liver enzymology MeSH
- Carcinogens metabolism toxicity MeSH
- Aristolochic Acids metabolism toxicity MeSH
- Inactivation, Metabolic MeSH
- Mice MeSH
- NADPH-Ferrihemoprotein Reductase genetics metabolism MeSH
- Kidney Diseases chemically induced enzymology MeSH
- Urologic Neoplasms chemically induced enzymology MeSH
- Urothelium MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comment MeSH
- Names of Substances
- aristolochic acid I MeSH Browser
- Carcinogens MeSH
- Aristolochic Acids MeSH
- NADPH-Ferrihemoprotein Reductase MeSH
Ingestion of aristolochic acid (AA) is associated with the development of AA-nephropathy and Balkan endemic nephropathy, which are characterized by chronic renal failure, tubulointerstitial fibrosis, and urothelial cancer. Understanding which enzymes are involved in AA activation and/or detoxification is important in assessing susceptibility to AA. Xiao et al. demonstrate that hepatic cytochrome P450s in mice detoxicate AA and thereby protect kidney from injury. The relative contribution of enzymes activating AA to induce urothelial cancer in humans remains to be resolved.
References provided by Crossref.org
Balkan endemic nephropathy: an update on its aetiology
