Biotransformation enzymes in development of renal injury and urothelial cancer caused by aristolochic acid
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, komentáře
PubMed
18480852
DOI
10.1038/ki.2008.125
PII: S0085-2538(15)52909-8
Knihovny.cz E-zdroje
- MeSH
- játra enzymologie MeSH
- karcinogeny metabolismus toxicita MeSH
- kyseliny aristolochové metabolismus toxicita MeSH
- metabolická inaktivace MeSH
- myši MeSH
- NADPH-cytochrom c-reduktasa genetika metabolismus MeSH
- nemoci ledvin chemicky indukované enzymologie MeSH
- urologické nádory chemicky indukované enzymologie MeSH
- urotel MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- komentáře MeSH
- Názvy látek
- aristolochic acid I MeSH Prohlížeč
- karcinogeny MeSH
- kyseliny aristolochové MeSH
- NADPH-cytochrom c-reduktasa MeSH
Ingestion of aristolochic acid (AA) is associated with the development of AA-nephropathy and Balkan endemic nephropathy, which are characterized by chronic renal failure, tubulointerstitial fibrosis, and urothelial cancer. Understanding which enzymes are involved in AA activation and/or detoxification is important in assessing susceptibility to AA. Xiao et al. demonstrate that hepatic cytochrome P450s in mice detoxicate AA and thereby protect kidney from injury. The relative contribution of enzymes activating AA to induce urothelial cancer in humans remains to be resolved.
Citace poskytuje Crossref.org
Balkan endemic nephropathy: an update on its aetiology
