Late blood pressure reduction in SHR subjected to transient captopril treatment in youth: possible mechanisms
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18597587
DOI
10.33549/physiolres.931615
PII: 1615
Knihovny.cz E-resources
- MeSH
- Antihypertensive Agents administration & dosage MeSH
- Hypertension drug therapy physiopathology MeSH
- Angiotensin-Converting Enzyme Inhibitors administration & dosage MeSH
- Captopril administration & dosage MeSH
- Blood Pressure drug effects MeSH
- Rats MeSH
- Disease Models, Animal MeSH
- Nifedipine pharmacology MeSH
- Rats, Inbred SHR MeSH
- Drug Administration Schedule MeSH
- Sympathetic Nervous System drug effects physiopathology MeSH
- Vasodilator Agents pharmacology MeSH
- Vasoconstriction drug effects MeSH
- Age Factors MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antihypertensive Agents MeSH
- Angiotensin-Converting Enzyme Inhibitors MeSH
- Captopril MeSH
- Nifedipine MeSH
- Vasodilator Agents MeSH
Spontaneously hypertensive rats (SHR) are characterized by enhanced nifedipine-sensitive component of sympathetic vasoconstriction. Our study tried to elucidate the mechanisms responsible for long-term reduction of blood pressure (BP) in SHR subjected to early transient captopril treatment. Adult untreated SHR aged 30-34 weeks were compared with animals subjected to chronic captopril treatment for 6 weeks either in youth (between 4 and 10 weeks of age) or in adulthood (between 24 and 30 weeks of age). Antihypertensive effects of captopril were more pronounced in young than adult SHR. This was due to greater attenuation of sympathetic and nifedipine-sensitive BP components and prevention of residual BP rise in young captopril-treated SHR in which the reductions of nifedipine-sensitive BP component and residual BP persisted for 20 weeks after captopril withdrawal. The magnitude of nifedipine-sensitive component of sympathetic vasoconstriction is decisive for BP maintenance not only in untreated SHR but also in SHR during active captopril treatment by or after its withdrawal.
References provided by Crossref.org
Altered Balance between Vasoconstrictor and Vasodilator Systems in Experimental Hypertension
Research on Experimental Hypertension in Prague (1966-2009)
