Novel pH-responsive nanoparticles
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18686981
DOI
10.1021/la801472x
Knihovny.cz E-resources
- MeSH
- Models, Chemical MeSH
- Electrolytes MeSH
- Phenylalanine chemistry MeSH
- Ions MeSH
- Hydrogen-Ion Concentration MeSH
- Micelles MeSH
- Microscopy, Atomic Force MeSH
- Nanoparticles chemistry MeSH
- Nanotechnology methods MeSH
- Plant Oils chemistry MeSH
- Polyethylene Glycols chemistry MeSH
- Polymers chemistry MeSH
- Surface Properties MeSH
- Scattering, Radiation MeSH
- Light MeSH
- Valine chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Electrolytes MeSH
- Phenylalanine MeSH
- Ions MeSH
- Micelles MeSH
- Plant Oils MeSH
- polyethylene glycol oleyl ether MeSH Browser
- Polyethylene Glycols MeSH
- Polymers MeSH
- Valine MeSH
In this work we report a new type of pH-responsive micelle-like nanoparticle. Reversible nanoscale structures are formed in solutions of a pH-sensitive hydrophobic polyelectrolyte, poly( N-methacryloyl- l-valine) or poly( N-methacryloyl- l-phenylalanine), and nonionic surfactant (Brij 98) in the presence of hydrochloric acid. The influence of composition and pH on particles size and shape was investigated by a variety of methods. An entity's size and polydispersity could be varied in a broad range making them a perspective candidate as a drug carrier. Unlike the case of typical micelles, our results indicate the presence of cavities in the formed particles. A hypothetical model of a nanoparticle and mechanism of formation are proposed.
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