Effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18940246
DOI
10.1016/j.reprotox.2008.09.007
PII: S0890-6238(08)00242-6
Knihovny.cz E-resources
- MeSH
- Androgen Antagonists toxicity MeSH
- Genitalia, Male drug effects embryology MeSH
- Mice, Inbred ICR MeSH
- Mice MeSH
- Oxazoles toxicity MeSH
- Fetus drug effects MeSH
- Reverse Transcriptase Polymerase Chain Reaction MeSH
- Fungicides, Industrial toxicity MeSH
- Spermatogenesis drug effects MeSH
- Pregnancy MeSH
- Body Weight drug effects MeSH
- Testis drug effects metabolism MeSH
- Ubiquitin metabolism MeSH
- Organ Size drug effects MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Androgen Antagonists MeSH
- Oxazoles MeSH
- Fungicides, Industrial MeSH
- Ubiquitin MeSH
- vinclozolin MeSH Browser
The effect of a low dose of vinclozolin within the development of the reproductive tract during gestation (VIN-GD 15-22) and puberty (VIN-PND 23-44) in CD1 mice was tested. We found a decrease in the anogenital distance, prostate weight and pathology of testes in both experimental groups. Sperm counts decreased to 46% (VIN-GD) and to 81% (VIN-PND), and also the acrosomal state (evaluated by antiacrosomal antibody) decreased in both groups to 89% in comparison to the control group (100%). Sperm head abnormalities increased by approximately 18% and 13%, respectively. In this connection, the expression of some genes was changed (arosome-related gene (Acr), apoptosis related genes (p53, p21)). In conclusion, a low dose of vinclozolin affected the reproductive tract, sperm parameters and expression of selected genes in both experimental groups.
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