Fluorescence properties of selected benzo[c]phenantridine alkaloids and studies of their interaction with CT DNA
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- benzofenantridiny chemie MeSH
- DNA chemie MeSH
- fluorescence * MeSH
- fluorescenční spektrometrie MeSH
- kvantová teorie MeSH
- reprodukovatelnost výsledků MeSH
- spektrofotometrie ultrafialová MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- benzofenantridiny MeSH
- calf thymus DNA MeSH Prohlížeč
- DNA MeSH
The spectral, especially fluorescence properties, of seven selected quaternary benzo[c]phenantridine alkaloids (sanguinarine, chelerythrine, chelirubine, sanguirubine, chelilutine, sanguilutine, and macarpine) were studied in presence and in absence of double-stranded DNA. This study has proved dramatic differences in fluorescence emission of all studied alkaloids in presence of calf thymus DNA in comparison to fluorescence of free alkaloids. The most remarkable are changes in emission spectra of macarpine, chelirubine, and sanguirubine. Association constants (logK) for interaction of all studied alkaloids with CT DNA were calculated.
Citace poskytuje Crossref.org
Quaternary Benzophenanthridine Alkaloids Act as Smac Mimetics and Overcome Resistance to Apoptosis
Seasonal variation of bioactive alkaloid contents in Macleaya microcarpa (Maxim.) Fedde
