Fluorescence properties of selected benzo[c]phenantridine alkaloids and studies of their interaction with CT DNA
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Benzophenanthridines chemistry MeSH
- DNA chemistry MeSH
- Fluorescence * MeSH
- Spectrometry, Fluorescence MeSH
- Quantum Theory MeSH
- Reproducibility of Results MeSH
- Spectrophotometry, Ultraviolet MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Benzophenanthridines MeSH
- calf thymus DNA MeSH Browser
- DNA MeSH
The spectral, especially fluorescence properties, of seven selected quaternary benzo[c]phenantridine alkaloids (sanguinarine, chelerythrine, chelirubine, sanguirubine, chelilutine, sanguilutine, and macarpine) were studied in presence and in absence of double-stranded DNA. This study has proved dramatic differences in fluorescence emission of all studied alkaloids in presence of calf thymus DNA in comparison to fluorescence of free alkaloids. The most remarkable are changes in emission spectra of macarpine, chelirubine, and sanguirubine. Association constants (logK) for interaction of all studied alkaloids with CT DNA were calculated.
References provided by Crossref.org
Quaternary Benzophenanthridine Alkaloids Act as Smac Mimetics and Overcome Resistance to Apoptosis
Seasonal variation of bioactive alkaloid contents in Macleaya microcarpa (Maxim.) Fedde
