The Role of PPARs in MDR - a lesson from embryonic development
Language English Country Slovakia Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- MeSH
- Embryo, Mammalian metabolism MeSH
- Embryonic Development physiology MeSH
- Humans MeSH
- Drug Resistance, Multiple * MeSH
- ATP Binding Cassette Transporter, Subfamily B metabolism MeSH
- Peroxisome Proliferator-Activated Receptors physiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- ATP Binding Cassette Transporter, Subfamily B MeSH
- Peroxisome Proliferator-Activated Receptors MeSH
One of the most important features of embryonic cells is their resistence to xenobiotics, which provides a natural protection for embryos against these potentially harmful molecules. In this way, embryo cells resemble cancer cells and thus understanding the basis of this phenomenon may contribute to overcoming the multi-drug-resistance (MDR) of some tumours. Peroxisome proliferator-activated receptors (PPARs) are steroid nuclear receptors that regulate diverse biological processes such as lipid and carbohydrate metabolism, development, differentiation, apoptosis, neoplastic transformation, inflammation and regeneration of tissues. Recently it has been found that they may also regulate the expression of some MDR proteins. In this article we summarise the main known relationships between some MDR pumps and three isoforms of PPAR receptors (PPAR-alpha, PPAR-beta/delta, PPAR-gamma). We hypothesize that regulation of MDR proteins by PPAR ligands in embryos could lead to the improvement of cancer treatment.
References provided by Crossref.org
Differential expression of ABC transporters (MDR1, MRP1, BCRP) in developing human embryos
