Neuroborreliosis is a form of borreliosis that affects the central and/or peripheral nervous system. Although it can mimic neurologic and ophthalmologic disorders such as multiple sclerosis and optic neuritis, visual evoked potential (VEP) examination is usually not used in neuroborreliosis diagnostics. Combined VEP testing (pattern-reversal VEPs and VEPs produced in response to linear and radial motion) was performed in 81 patients with neuroborreliosis verified by laboratory results (positive polymerase chain reaction or intrathecal antibodies production). Thirty-four patients reported diplopia or blurred vision related to borreliosis. In 33 (40%) patients the VEPs were delayed: motion-onset VEPs were pathologic in 22 (27%) patients, reversal VEPs in 5 (6%) patients, and both VEP types in 6 (7%) patients. The findings suggest that VEP testing (especially the motion-onset VEP testing) can confirm CNS involvement. Much higher sensitivity of motion-onset VEPs in comparison with reversal VEPs can result from rather selective (earlier) involvement of the magnocellular system or the dorsal stream of the visual pathway.

Department of Pathophysiology Charles University Prague Faculty of Medicine in Hradec Králové Czech Republic

Citace poskytuje Crossref.org

Optic nerve involvement in patients with Lyme neuroborreliosis: an electrophysiological study

VEP examination with new portable device

Effect of Dioptric Blur on Pattern-Reversal and Motion-Onset VEPs as Used in Clinical Research

Visual evoked and event-related brain potentials in HIV-infected adults: a longitudinal study over 2.5 years

Pattern- and motion-related visual evoked potentials in HIV-infected adults

Difficulties of motion-onset VEP interpretation in school-age children

Ophthalmological examination and VEPs in preterm children with perinatal CNS involvement