Silica encapsulated manganese perovskite nanoparticles for magnetically induced hyperthermia without the risk of overheating
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19531865
DOI
10.1088/0957-4484/20/27/275610
PII: S0957-4484(09)09233-2
Knihovny.cz E-resources
- MeSH
- Electromagnetic Fields MeSH
- Hyperthermia, Induced methods MeSH
- Calorimetry MeSH
- Hydrogen-Ion Concentration MeSH
- Manganese chemistry MeSH
- Nanoparticles chemistry ultrastructure MeSH
- Silicon Dioxide chemistry MeSH
- Oxides chemistry MeSH
- Calcium Compounds chemistry MeSH
- Spectrophotometry, Infrared MeSH
- Materials Testing methods MeSH
- Titanium chemistry MeSH
- Microscopy, Electron, Transmission MeSH
- Particle Size MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Manganese MeSH
- Silicon Dioxide MeSH
- Oxides MeSH
- perovskite MeSH Browser
- Calcium Compounds MeSH
- Titanium MeSH
Nanoparticles of manganese perovskite of the composition La(0.75)Sr(0.25)MnO(3) uniformly coated with silica were prepared by encapsulation of the magnetic cores (mean crystallite size 24 nm) using tetraethoxysilane followed by fractionation. The resulting hybrid particles form a stable suspension in an aqueous environment at physiological pH and possess a narrow hydrodynamic size distribution. Both calorimetric heating experiments and direct measurements of hysteresis loops in the alternating field revealed high specific power losses, further enhanced by the encapsulation procedure in the case of the coated particles. The corresponding results are discussed on the basis of complex characterization of the particles and especially detailed magnetic measurements. Moreover, the Curie temperature (335 K) of the selected magnetic cores resolves the risk of local overheating during hyperthermia treatment.
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