The association between glutathione S-transferase gene polymorphisms and pancreatic cancer in a central European Slavonic population
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19786118
DOI
10.1016/j.mrgentox.2009.09.005
PII: S1383-5718(09)00333-7
Knihovny.cz E-resources
- MeSH
- Adenocarcinoma epidemiology genetics pathology MeSH
- DNA blood MeSH
- Adult MeSH
- Genetic Predisposition to Disease * MeSH
- Glutathione S-Transferase pi genetics MeSH
- Glutathione Transferase genetics MeSH
- Polymorphism, Single Nucleotide * MeSH
- Middle Aged MeSH
- Humans MeSH
- Pancreatic Neoplasms epidemiology genetics pathology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic epidemiology MeSH
- Names of Substances
- DNA MeSH
- Glutathione S-Transferase pi MeSH
- glutathione S-transferase T1 MeSH Browser
- Glutathione Transferase MeSH
- GSTP1 protein, human MeSH Browser
In the first case-control study on pancreatic cancer conducted on 253 cases and 403 controls in the Czech Republic we observed that the GSTP1-codon 105 Val variant allele and the GSTT1-null genotype were associated with an elevated risk for pancreatic cancer (OR = 1.38; 95%CI = 0.96-1.97 and OR = 1.56; 95%CI = 0.93-2.61, respectively). Combination of GSTT1-null and GSTP1-codon 105 Val variants further increased the risk for pancreatic cancer (OR = 2.50; 95%CI = 1.20-5.20). In conclusion, this study suggests population-specific associations of polymorphisms in key biotransformation genes with elevated risk for pancreatic cancer.
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