Effect of methamphetamine exposure and cross-fostering on cognitive function in adult male rats
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19900489
DOI
10.1016/j.bbr.2009.11.001
PII: S0166-4328(09)00666-4
Knihovny.cz E-resources
- MeSH
- Analysis of Variance MeSH
- Maze Learning drug effects MeSH
- Time Factors MeSH
- Behavior, Animal MeSH
- Cognition Disorders chemically induced MeSH
- Rats MeSH
- Maternal Behavior physiology MeSH
- Methamphetamine adverse effects MeSH
- Neuropsychological Tests MeSH
- Animals, Newborn MeSH
- Foster Home Care psychology MeSH
- Swimming psychology MeSH
- Reaction Time physiology MeSH
- Retention, Psychology drug effects physiology MeSH
- Chi-Square Distribution MeSH
- Central Nervous System Stimulants adverse effects MeSH
- Pregnancy MeSH
- Prenatal Exposure Delayed Effects physiopathology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Methamphetamine MeSH
- Central Nervous System Stimulants MeSH
The aim of our study was to examine the effect of prenatal methamphetamine (MA) exposure and cross-fostering on cognitive functions of adult male rats tested in Morris water maze (MWM). Rat mothers were exposed daily to injection of MA (5mg/kg) or saline for 9 weeks: prior to impregnation, throughout gestation and lactation periods. Females without any injections were used as an absolute control. On postnatal day 1, pups were cross-fostered so that each mother raised 4 pups of her own and 8 pups from the mothers with the other two treatments. Four types of tests were used: (1) Place navigation test (Learning), (2) Probe test (Probe), (3) Retention memory test (Memory) and (4) Visible platform task. Our results demonstrate that the prenatal exposure to MA does not impact learning and memory, while postnatal exposure to MA shows impairments in cognition. In the test of learning, all animals fostered to MA-treated dams had longer latencies, bigger search error and used lower spatial strategies than the animals fostered to control or saline-treated mother, regardless of prenatal exposure. Regardless of postnatal exposure, the animals prenatally exposed to saline swam faster in all the tests than the animals prenatally exposed to MA and controls, respectively. This study indicates that postnatal but not prenatal exposure to MA affects learning in adult male rats. However, it is still not clear whether these impairments are due to a direct effect of MA on neuronal structure or due to an indirect effect of MA mediated by impaired maternal care.
References provided by Crossref.org
Perinatal Stress and Methamphetamine Exposure Decreases Anxiety-Like Behavior in Adult Male Rats
The Impact of Neonatal Methamphetamine on Spatial Learning and Memory in Adult Female Rats
Prenatal Exposure to Methamphetamine: Up-Regulation of Brain Receptor Genes
Early Postnatal Stress Impairs Cognitive Functions of Male Rats Persisting Until Adulthood
