The Fischer 344 rat as a model of presbycusis
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
19903514
DOI
10.1016/j.heares.2009.11.003
PII: S0378-5955(09)00279-2
Knihovny.cz E-zdroje
- MeSH
- akustická stimulace MeSH
- chování zvířat MeSH
- kochlea patologie patofyziologie MeSH
- krysa rodu Rattus MeSH
- modely nemocí na zvířatech * MeSH
- otoakustické emise spontánní MeSH
- potkani inbrední F344 * MeSH
- presbyakuze patologie patofyziologie psychologie terapie MeSH
- psychoakustika MeSH
- sluchová dráha patologie patofyziologie MeSH
- sluchová percepce MeSH
- sluchový práh MeSH
- stárnutí * MeSH
- věkové faktory MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Due to the rising number of the aged human population all over the world, presbycusis is a phenomenon that deserves the increasing attention of the medical community as regards to prevention and treatment. This requires finding appropriate animal models for human presbycusis that will be useful in future experiments. Among the available rat strains, the Fischer 344 (F344) strain promises to serve as a model producing prompt and profound presbycusis. Hearing thresholds begin to increase in this strain during the first year of life; toward the end of the second year, the thresholds are very high. The threshold shifts progress independently in both ears. The rapid deterioration of distortion product otoacoustic emissions, with the majority of outer hair cells (OHC) being present and morphologically intact, is apparently produced by the disruption of prestin. The age-related changes within inner ear function are accompanied by deterioration of acoustical signal processing within central auditory system, mainly due to impaired GABA inhibition. The loss of GABA inhibition in old animals is expressed primarily in the inferior colliculus but is also present in the cochlear nuclei and the auditory cortex. Sound-evoked behavioral reactions are also impaired in old F344 rats. Taken together, the described characteristics of the aging F344 rat auditory system supports the idea that this strain may serve as a suitable model for studying the mechanisms of presbycusis, its prevention and treatment.
Citace poskytuje Crossref.org
Functional Age-Related Changes Within the Human Auditory System Studied by Audiometric Examination
Functional changes in the human auditory cortex in ageing
Immunocytochemical profiles of inferior colliculus neurons in the rat and their changes with aging
