The importance of serum levels of selected biological parameters in the diagnosis, staging and prognosis of multiple myeloma
Jazyk angličtina Země Slovensko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
20099972
DOI
10.4149/neo_2010_02_102
Knihovny.cz E-zdroje
- MeSH
- diferenciální diagnóza MeSH
- dospělí MeSH
- ELISA MeSH
- hepatocytární růstový faktor krev MeSH
- kolagen typu I MeSH
- lidé středního věku MeSH
- lidé MeSH
- mnohočetný myelom krev diagnóza MeSH
- monoklonální gamapatie nejasného významu krev diagnóza MeSH
- nádorové biomarkery krev MeSH
- osteoprotegerin krev MeSH
- peptidové fragmenty krev MeSH
- peptidy MeSH
- prognóza MeSH
- prokolagen krev MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- staging nádorů MeSH
- syndekan-1 krev MeSH
- vaskulární endoteliální růstový faktor A krev MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- collagen type I trimeric cross-linked peptide MeSH Prohlížeč
- hepatocytární růstový faktor MeSH
- HGF protein, human MeSH Prohlížeč
- kolagen typu I MeSH
- nádorové biomarkery MeSH
- osteoprotegerin MeSH
- peptidové fragmenty MeSH
- peptidy MeSH
- procollagen Type I N-terminal peptide MeSH Prohlížeč
- prokolagen MeSH
- SDC1 protein, human MeSH Prohlížeč
- syndekan-1 MeSH
- TNFRSF11B protein, human MeSH Prohlížeč
- vaskulární endoteliální růstový faktor A MeSH
- VEGFA protein, human MeSH Prohlížeč
The study aimed at evaluating the relation of 7 parameters associated with the internal biological properties of myeloma cells and the bone marrow microenvironment to multiple myeloma (MM) stages, distinguishing its initial/asymptomatic phase from monoclonal gammopathy of undetermined significance (MGUS) and assessing their relation to myeloma prognosis. In the studied group comprising 286 individuals (89 MGUS and 179 MM patients), statistically significant differences (Mann-Whitney test) between MGUS and MM at the time of diagnosis were found in the serum levels of HGF (hepatocyte growth factor), VEGF (vascular endothelial growth factor), ICTP (intercellular - carboxy-terminal telopeptide of type I collagen), PINP (procollagen type I N-terminal propeptide), OPG (osteoprotegerin) and syndecan-1/CD138, but not in Fas. Multivariate analysis (logistic regression) revealed an unsatisfactory potential of all the 7 studied indicators to discriminate between MGUS and MM. A deeper analysis showed statistically significant differences between MGUS and the initial/asymptomatic phase of MM (stage 1 according to the International Staging System) only in the cases of syndecan-1 (p=0.001) and Fas (p=0.008). The assessment of initial values of HGF, VEGF, ICTP, PINP, OPG, syndecan-1 and Fas showed a statistically significant relation (log rank test) to the overall survival (OS) in a group of 132 patients treated with conventional chemotherapy only in the cases of syndecan-1 (p=0.0002) and Fas (p=0.018), but in none of the investigated parameters in a group of 74 patients treated with HDT/ASCT (high-dose therapy/autologous stem cell transplantation). The analysis showed that, despite significant differences in serum levels of 6 of the 7 studied parameters found between MGUS and MM, none of the markers may be included in the spectrum of indicators used to distinguish the two conditions. Despite the positive relation, especially of syndecan-1 and, to a lesser extent, of Fas to the OS in patients treated with conventional chemotherapy, these prognostic factors are not applicable to HDT/ASCT.
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