Susceptibility of Staphylococcus aureus strains toward combinations of oxacillin-2,4-dihydroxychalcone
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- antibakteriální látky farmakologie MeSH
- chalkonoidy farmakologie MeSH
- lékové interakce MeSH
- lidé MeSH
- mikrobiální testy citlivosti MeSH
- nefelometrie a turbidimetrie MeSH
- oxacilin farmakologie MeSH
- Staphylococcus aureus účinky léků růst a vývoj MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 2',4'-dihydroxychalcone MeSH Prohlížeč
- antibakteriální látky MeSH
- chalkonoidy MeSH
- oxacilin MeSH
In order to determine the existence of synergism of the bacteriostatic action of flavonoids against G(+) bacteria between a clinically interesting conventional antibiotic and a flavonoid, combinations of oxacillin (OXC) and 2,4-dihydroxychalcone (DCH) as enhancer were assayed against methicillin-sensitive Staphylococcus aureus ATCC 29 213 and methicillin-resistant S. aureus ATCC 43 300. Using a kinetic-turbidimetric method, growth kinetics was monitored in a broth containing variable amounts of OXC alone and combinations of variable OXC-constant DCH. The minimum inhibitory concentrations (MIC) of OXC alone and in combination with DCH were evaluated. For the 29 213 strain, OXC MIC was 25 microg/mL, while combinations of 2-8 microg/mL OXC with 10 microg/mL of DCH totally inhibited growth and showed synergism. The resistance of the 43 300 strain in the presence of OXC was verified; OXC-DCH combinations decreased bacterial growth by 35 %. DCH augments the action of OXC against methicillin-susceptible S. aureus and therefore constitutes a good bacteriostatic agent for methicillin-resistant S. aureus.
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Emerg Infect Dis. 2005 Apr;11(4):526-32 PubMed
Ann Intern Med. 1982 Sep;97(3):325-9 PubMed
Fitoterapia. 2002 Oct;73(6):536-9 PubMed
J Infect Dis. 2005 Sep 1;192(5):811-8 PubMed
Fitoterapia. 2007 Dec;78(7-8):565-70 PubMed
Folia Microbiol (Praha). 2008;53(1):23-8 PubMed
Biocell. 2006 Apr;30(1):39-42 PubMed
J Med Chem. 1996 Feb 2;39(3):673-9 PubMed
Pharmacol Rev. 2000 Dec;52(4):673-751 PubMed
Phytomedicine. 2000 Apr;7(2):161-5 PubMed
Proc Natl Acad Sci U S A. 2002 May 28;99(11):7687-92 PubMed
Biocell. 2004 Apr;28(1):31-4 PubMed
Phytochemistry. 1998 May;48(1):125-9 PubMed
Int J Antimicrob Agents. 2005 Nov;26(5):343-56 PubMed
Biochem Pharmacol. 1983 Apr 1;32(7):1141-8 PubMed
Clin Infect Dis. 2003 Nov 15;37(10):1313-9 PubMed
N Engl J Med. 2005 Apr 7;352(14):1436-44 PubMed
Int J Antimicrob Agents. 2004 May;23(5):462-7 PubMed
