Virulence profile and clonal relationship among the Vibrio cholerae isolates from ground and surface water in a cholera endemic area during rainy season
Language English Country United States Media print-electronic
Document type Journal Article
- MeSH
- Bacterial Proteins genetics MeSH
- Cholera epidemiology microbiology MeSH
- DNA Fingerprinting MeSH
- DNA-Binding Proteins genetics MeSH
- Endemic Diseases * MeSH
- Virulence Factors genetics MeSH
- Genotype MeSH
- Hemolysin Proteins genetics MeSH
- Humans MeSH
- Water Microbiology * MeSH
- Bacterial Outer Membrane Proteins genetics MeSH
- Seasons MeSH
- Cluster Analysis MeSH
- Bacterial Typing Techniques MeSH
- Transcription Factors genetics MeSH
- Vibrio cholerae classification isolation & purification pathogenicity MeSH
- Virulence MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- India epidemiology MeSH
- Names of Substances
- Bacterial Proteins MeSH
- DNA-Binding Proteins MeSH
- Virulence Factors MeSH
- Hemolysin Proteins MeSH
- hlyA protein, Vibrio cholerae MeSH Browser
- Bacterial Outer Membrane Proteins MeSH
- toxR protein, Vibrio cholerae MeSH Browser
- Transcription Factors MeSH
All the V. cholerae non-O1, non-O139 isolates from ground and surface water samples collected during the rainy season (rainfall contributes significantly in the spread of cholera) contained ompW and a regulatory toxR gene, while many others possessed accessory cholera toxin (ace), hemolysin (hlyA) and outer membrane protein (ompU) genes. All the isolates lacked ctxAB, tcp, zot, rfbO1 and rfbO139 genes. The strains could be grouped into two main clusters colligating the isolates from ground water and surface water samples. The results suggest that surface water harbors various virulent V. cholerae strains that contaminate the ground water due to rain or poor hygienic practices, and result in the emergence of new toxigenic strains for cholera.
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