A FTO variant and risk of acute coronary syndrome

. 2010 Aug 05 ; 411 (15-16) : 1069-72. [epub] 20100401

Jazyk angličtina Země Nizozemsko Médium print-electronic

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/pmid20362563
Odkazy

PubMed 20362563
DOI 10.1016/j.cca.2010.03.037
PII: S0009-8981(10)00226-3
Knihovny.cz E-zdroje

BACKGROUND: The FTO gene plays an important role in the determination of body weight and BMI and it has been suspected of being associated with all-case mortality. METHODS: We have analyzed the FTO rs17817449 variant in consecutive 1092 male patients with acute coronary syndrome (ACS) and in 1191 randomly selected Caucasian individuals (population controls). RESULTS: The FTO variant was significantly associated with BMI both in controls (P<0.02) and ACS patients (P<0.01). In both groups, BMI was highest in GG homozygotes and lowest in TT homozygotes. There was a significant difference between the ACS patients and controls in the frequency of the FTO genotype GG (21.4% vs. 15.9%, P<0.005). FTO GG homozygotes had a significantly increased risk of ACS, compared with TT homozygotes which was independent of age and BMI (odds ratio 1.49, 95% confidence interval 1.16-1.93). The odds ratio of ACS patients for the GG genotype remained significant even after the exclusion of diabetics (100 controls and 339 ACS patients), with OR 1.32 (95% CI 1.01-1.72). CONCLUSIONS: This study provides an evidence of an association between the FTO variant and risk of ACS in Caucasian males.

Citace poskytuje Crossref.org

Nejnovějších 20 citací...

Zobrazit více v
Medvik | PubMed

FTO in health and disease

. 2024 ; 12 () : 1500394. [epub] 20241218

APOL1 polymorphisms are not influencing acute coronary syndrome risk in Czech males

. 2024 Aug ; 12 (8) : e2449.

Epitranscriptomic Regulations in the Heart

. 2024 Apr 18 ; 73 (Suppl 1) : S185-S198. [epub] 20240418

RNA modification m6Am: the role in cardiac biology

. 2023 Dec ; 18 (1) : 2218771.

ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors

. 2021 Aug ; 519 () : 206-209. [epub] 20210503

Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management?

. 2021 Apr 17 ; 22 (8) : . [epub] 20210417

Rs6922269 marker at the MTHFD1L gene predict cardiovascular mortality in males after acute coronary syndrome

. 2015 Aug ; 42 (8) : 1289-93. [epub] 20150326

The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population

. 2012 Mar ; 27 (3) : 1030-5. [epub] 20110725

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...