Characterization of pseudacyclins A-E, a suite of cyclic peptides produced by Pseudallescheria boydii
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20509707
DOI
10.1021/np900472c
Knihovny.cz E-resources
- MeSH
- Peptides, Cyclic chemistry isolation & purification MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Molecular Structure MeSH
- Mice MeSH
- Nuclear Magnetic Resonance, Biomolecular MeSH
- Pseudallescheria chemistry pathogenicity MeSH
- Amino Acid Sequence MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Peptides, Cyclic MeSH
Pseudallescheria boydii sensu lato is an emerging fungal pathogen causing fatal infections in both immunocompromised and immunocompetent hosts. In this work, two P. boydii isolates (human and animal origin) have been identified as being producers of cyclic peptides. Five putative nonribosomal peptides with a unique structure, which have been named pseudacyclins, were characterized by nuclear magnetic resonance spectroscopy and mass spectrometry. The most abundant representative of the pseudacyclins was quantified also on fungal spores. The presence of these peptides on inhaled fungal spores creates the possibility for exploitation of pseudacyclins as early indicators of fungal infections caused by Pseudallescheria species.
References provided by Crossref.org
CYCLONE--a utility for de novo sequencing of microbial cyclic peptides
