Left atrial flow propagation velocity: a new approach for assessment of left atrial reservoir function
Language English Country United States Media print-electronic
Document type Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Analysis of Variance MeSH
- Echocardiography, Doppler, Color * MeSH
- Adult MeSH
- Hemodynamics * MeSH
- Humans MeSH
- Young Adult MeSH
- Nitroglycerin administration & dosage MeSH
- Observer Variation MeSH
- Compliance MeSH
- Predictive Value of Tests MeSH
- Echocardiography, Doppler, Pulsed * MeSH
- Reproducibility of Results MeSH
- Blood Flow Velocity MeSH
- Atrial Function, Left * MeSH
- Heart Atria diagnostic imaging physiopathology MeSH
- Feasibility Studies MeSH
- Muscle Contraction MeSH
- Valsalva Maneuver MeSH
- Vasodilator Agents administration & dosage MeSH
- Pulmonary Veins diagnostic imaging physiopathology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Evaluation Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Nitroglycerin MeSH
- Vasodilator Agents MeSH
To assess the feasibility of left atrial flow propagation velocity (LAFPV) measurement and to evaluate the influence of preload alterations on this new parameter of left atrial (LA) reservoir function as compared to conventional echocardiographic indices. 30 healthy volunteers (26 ± 5 years, 20 males) underwent echocardiographic examination at rest, during passive leg lifting and after sublingual administration of nitroglycerine with subsequent Valsalva maneuver. LA reservoir function was assessed by conventional indices including LA expansion index, peak velocity and velocity-time integral of pulmonary venous systolic flow. As well, LAFPV was measured by color M-mode in an apical 4-chamber view as the slope of the transatrial flow wave during LA reservoir phase. LAFPV measurement was feasible in 25 subjects (83%). All conventional parameters of LA reservoir function were significantly altered from resting values by both load-modifying conditions. However, LAPFV was not significantly altered by such maneuvers (228 ± 28 cm s⁻¹ at rest vs. 238 ± 3 cm s⁻¹ during leg lifting, P = NS, vs. 218 ± 38 cm s(-1) after nitroglycerin with Valsalva maneuver, P = NS vs. rest, P < 0.01 vs. leg lifting). LAFPV can be measured in a majority of subjects and represents a new, less load-dependent index of LA reservoir function that may more appropriately reflect LA compliance.
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