Changes in hemocoagulation in acute stroke patients after one-hour sono-thrombolysis using a diagnostic probe
Language English Country England, Great Britain Media print
Document type Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
PubMed
20620692
DOI
10.1016/j.ultrasmedbio.2010.04.010
PII: S0301-5629(10)00188-2
Knihovny.cz E-resources
- MeSH
- Acute Disease MeSH
- Equipment Failure Analysis MeSH
- Stroke diagnostic imaging physiopathology therapy MeSH
- Equipment Design MeSH
- Adult MeSH
- Echoencephalography instrumentation MeSH
- Blood Coagulation radiation effects MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Aged MeSH
- Thrombolytic Therapy instrumentation methods MeSH
- Ultrasonic Therapy instrumentation methods MeSH
- Sonication instrumentation MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
The aim was to monitor the changes in hemocoagulation parameters in acute ischemic stroke (AIS) patients after sono-thrombolysis of the occluded middle cerebral artery using a duplex transcranial probe with 2.0-MHz frequency in Doppler mode. Sixteen AIS patients indicated for intravenous thrombolysis (IVT) (8 males; mean age 68.3 +/- 7.1 y) and 16 AIS patients contraindicated for IVT (11 males; mean age 67.9 +/- 7.9 y) were randomized for sono-thrombolysis (8 + 8 patients) or standard treatment (control group) (8 + 8 patients). The significant decrease of plasminogen activator inhibitor-1, plasminogen and alpha-2-antiplasmin activity by a mean of 60, 32 and 24%, respectively, and the increase of tissue plasminogen activator by a mean of 56% was found after sono-thrombolysis when compared with control group (p < 0.0125); these changes were more evident in patients treated with a combination of sono-thrombolysis and IVT (79, 38, 50 and 82%, respectively) than in patients treated by sono-thrombolysis alone (34, 13, 17 and 30%, respectively).
References provided by Crossref.org
Sonolysis during carotid endarterectomy: randomised controlled trial
