Sesquiterpene lactone trilobolide activates production of interferon-γ and nitric oxide
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20727953
DOI
10.1016/j.fitote.2010.08.005
PII: S0367-326X(10)00206-6
Knihovny.cz E-resources
- MeSH
- Butyrates chemistry pharmacology MeSH
- Egtazic Acid analogs & derivatives pharmacology MeSH
- Furans chemistry pharmacology MeSH
- Interferon-gamma metabolism MeSH
- Rats MeSH
- Humans MeSH
- Molecular Structure MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Neutrophils drug effects metabolism MeSH
- Nitric Oxide metabolism MeSH
- Peritoneum cytology MeSH
- Rats, Inbred Lew MeSH
- Cell Survival MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Humans MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester MeSH Browser
- Butyrates MeSH
- Egtazic Acid MeSH
- Furans MeSH
- Interferon-gamma MeSH
- Nitric Oxide MeSH
- trilobolide MeSH Browser
Trilobolide (TB), a sesquiterpene lactone isolated from Laser trilobum is an inhibitor of sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA). We have found that upon the in vitro exposure to TB, rodent peritoneal cells and human peripheral blood mononuclear cells secrete high amounts of IFN-γ. The effect is associated with the stimulation of high output NO biosynthesis in rat cells. The stimulatory potential of TB depends on the activation of MAP kinases p38 and ERK1/2, and transcription factor NF-κB. BAPTA-AM, a chelator of the intracellular calcium, remained without any effect on the secretion of IFN-γ triggered by TB. These results demonstrate that TB is a potent immunostimulatory agent.
References provided by Crossref.org
BODIPY-based fluorescent liposomes with sesquiterpene lactone trilobolide
