The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
21310158
DOI
10.1016/j.ijpara.2011.01.003
PII: S0020-7519(11)00033-6
Knihovny.cz E-resources
- MeSH
- Time Factors MeSH
- Insect Vectors immunology parasitology physiology MeSH
- Bites and Stings immunology parasitology MeSH
- Leishmania major physiology MeSH
- Leishmaniasis, Cutaneous immunology parasitology prevention & control MeSH
- Humans MeSH
- Mice, Inbred BALB C MeSH
- Mice MeSH
- Phlebotomus immunology parasitology physiology MeSH
- Saliva immunology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Under laboratory conditions, hosts exposed twice to sand fly saliva are protected against severe leishmaniasis. However, people in endemic areas are exposed to the vector over a long term and may experience sand fly-free periods. Therefore, we exposed mice long- or short-term to Phlebotomus duboscqi bites, followed by Leishmania major infection either immediately or after a sand fly-free period. We showed that protection against leishmaniasis is limited to short-term exposure to sand flies immediately before infection. Our results may explain the persistence of leishmaniasis in endemic areas and should be taken into account when designing anti-Leishmania vaccines based on sand fly saliva.
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