The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
21310158
DOI
10.1016/j.ijpara.2011.01.003
PII: S0020-7519(11)00033-6
Knihovny.cz E-zdroje
- MeSH
- časové faktory MeSH
- hmyz - vektory imunologie parazitologie fyziologie MeSH
- kousnutí a bodnutí imunologie parazitologie MeSH
- Leishmania major fyziologie MeSH
- leishmanióza kožní imunologie parazitologie prevence a kontrola MeSH
- lidé MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- Phlebotomus imunologie parazitologie fyziologie MeSH
- sliny imunologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Under laboratory conditions, hosts exposed twice to sand fly saliva are protected against severe leishmaniasis. However, people in endemic areas are exposed to the vector over a long term and may experience sand fly-free periods. Therefore, we exposed mice long- or short-term to Phlebotomus duboscqi bites, followed by Leishmania major infection either immediately or after a sand fly-free period. We showed that protection against leishmaniasis is limited to short-term exposure to sand flies immediately before infection. Our results may explain the persistence of leishmaniasis in endemic areas and should be taken into account when designing anti-Leishmania vaccines based on sand fly saliva.
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