Oxidative stress response and virulence factors in Candida glabrata clinical isolates
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- biofilmy růst a vývoj MeSH
- Candida glabrata účinky léků izolace a purifikace patogenita fyziologie MeSH
- diamid toxicita MeSH
- faktory virulence metabolismus MeSH
- fosfolipasy metabolismus MeSH
- fyziologický stres * MeSH
- hydrofobní a hydrofilní interakce MeSH
- kandidóza mikrobiologie MeSH
- lidé MeSH
- nemocnice fakultní MeSH
- oxidační stres * MeSH
- oxidancia toxicita MeSH
- peroxid vodíku toxicita MeSH
- proteasy metabolismus MeSH
- reaktivní formy kyslíku metabolismus MeSH
- triaziny toxicita MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Slovenská republika MeSH
- Názvy látek
- 7-chlorotetrazolo(5,1-c)benzo(1,2,4)triazine MeSH Prohlížeč
- diamid MeSH
- faktory virulence MeSH
- fosfolipasy MeSH
- oxidancia MeSH
- peroxid vodíku MeSH
- proteasy MeSH
- reaktivní formy kyslíku MeSH
- triaziny MeSH
We determined the susceptibility to oxidative stress and assessed the four virulence factors of the 38 Candida glabrata clinical isolates originating from two teaching hospitals in Slovakia. All the isolates were susceptible to hydrogen peroxide, diamide, and 7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine (CTBT) inducing an increased formation of reactive oxygen species in fungal cells. The mean relative cell surface hydrophobicity (CSH) of isolates was 21.9, ranging from 1.92 to 56.96. All isolates showed biofilm formation. A high biofilm formation was observed among 60.5% of isolates. Positive correlations were observed between biofilm formation and moderate values of CSHs. The 76.3% and 84.2% of isolates displayed varying degrees of proteinase and phospholipase activity, respectively. These results demonstrate a differential distribution of factors contributing to virulence of C. glabrata clinical isolates and point to their significance in pathogenesis that would be targeted by novel antifungals.
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