Cancer immunology and colorectal cancer recurrence
Language English Country Singapore Media electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
21622278
DOI
10.2741/233
PII: 233
Knihovny.cz E-resources
- MeSH
- Immunotherapy methods MeSH
- Colorectal Neoplasms immunology physiopathology therapy MeSH
- Humans MeSH
- Neoplasm Recurrence, Local immunology prevention & control MeSH
- Neoplasm Metastasis immunology prevention & control MeSH
- NF-kappa B metabolism MeSH
- STAT3 Transcription Factor metabolism MeSH
- Inflammation immunology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- NF-kappa B MeSH
- STAT3 protein, human MeSH Browser
- STAT3 Transcription Factor MeSH
The recurrence of a cancer - local or distant (metastasis) - is manifested by the persistence of cancer cells in the organism after the ablation of the primary lesion, an ineffective anticancer immune response, and by the activity of biological/immunological factors that can stimulate and sustain its development. This review focuses on colorectal carcinoma and discusses some aspects of cancer immunology regarding cancer development and its recurrence. It is addressed also to the clinician to provide new insights helpful for designing better therapeutic strategies and patient's follow up. Therapeutic approaches used during and after surgical treatments, found capable of modulating immunity (differently affecting disease outcome), will also be described.
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